AI Article Synopsis
- Two new compounds, 12,13-dihydro-12,13-dihydroxybakuchiol and (12'S)-bisbakuchiol C, were discovered from the seeds of the Psoralea corylifolia plant.
- The structures of these compounds were determined using various scientific methods, including spectroscopy.
- Several isolated meroterpenoids and their analogues were tested for their ability to inhibit specific cellular pathways, with some showing effectiveness without harming cell viability in cancer cell lines.
Article Abstract
Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12'S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-kappaB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-kappaB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.
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| http://dx.doi.org/10.1016/j.bmcl.2008.03.028 | DOI Listing |
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