Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0140-6736(08)60450-X | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Non-pharmacological interventions (NPIs) are preferred alternatives to using antipsychotic medications to manage disruptive behaviors in nursing home (NH) residents living with dementia. However, the implementation of these interventions is often complex in the NH environment. In this qualitative analysis of data from an embedded pragmatic clinical trial (ePCT) of a personalized music intervention, we describe NH-level implementation barriers and facilitators.
View Article and Find Full Text PDFImmunohistochemical basis for FAP as a candidate theranostic target across a broad range of cholangiocarcinoma subtypes.
Front Nucl Med
November 2024
Department of Radiology, Mayo Clinic, Rochester, MN, United States.
Article Synopsis
- This study investigates the expression and location of fibroblast activation protein (FAP) in various liver tumors, focusing on cholangiocarcinoma (CCA), hepatocellular carcinoma (HCC), hepatocellular adenoma (HCA), and focal nodular hyperplasia (FNH).
- FAP immunostaining results showed that a high percentage of CCA exhibited moderate to strong FAP expression compared to other tumor types, indicating a significant distinction.
- The findings suggest that FAP is consistently present in CCA tumor stroma regardless of clinical features, highlighting its potential as a target for future diagnostic and therapeutic strategies in treating different CCA subtypes.
Implementation facilitators and barriers of stress first aid to protect mental health of frontline health care workers during the COVID-19 pandemic: a qualitative study.
BMC Health Serv Res
November 2024
RAND Corporation, Boston, MA, USA.
Background: The COVID-19 pandemic has taken a toll on frontline health care workers (HCWs), leading to poor mental and physical well-being. We conducted a large, cluster randomized controlled trial to implement an adapted Stress First Aid (SFA) intervention to support HCW well-being using a train-the-trainer (TTT) approach for rapid deployment in the United States and collected qualitative data through interviews to understand implementation. The goal of this study is to understand barriers and facilitators to deploying SFA using a TTT model, with particular emphasis on the acceptability, uptake, and barriers from the implementation.
View Article and Find Full Text PDFBLU-945, a potent and selective next-generation EGFR TKI, has antitumor activity in models of osimertinib-resistant non-small-cell lung cancer.
Ther Adv Med Oncol
October 2024
Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.
Article Synopsis
- Many non-small-cell lung cancer (NSCLC) patients develop resistance to existing EGFR tyrosine kinase inhibitors (TKIs), particularly due to _C797S mutations that render osimertinib ineffective.
- BLU-945 is a new orally available EGFR-TKI that effectively targets both activating and resistance mutations, including EGFR_C797S, showing significant potency while sparing healthy EGFR.
- In preclinical and early clinical studies, BLU-945 demonstrated promising results, inhibiting tumor growth in resistant models and patients, suggesting it could be a viable treatment option for NSCLC patients who no longer respond to osimertinib.
A community-academic partnership to develop an implementation support package for overdose prevention in permanent supportive housing.
J Subst Use Addict Treat
January 2025
Department of Emergency Medicine, NYU School of Medicine, New York, NY, United States of America; Department of Population Health, NYU School of Medicine, New York, NY, United States of America. Electronic address:
Introduction: The overdose crisis in the U.S. disproportionately impacts people experiencing homelessness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!