Both the type and amount of carbohydrate found in foods influence postprandial glucose levels and can also affect overall glycemic control in individuals with diabetes. This review, based on the American Diabetes Association's Nutrition Recommendations and Interventions for Diabetes, and the American Dietetic Association's Evidence Analysis Library (Diabetes 1 and 2), provides a description and interpretation of the clinical studies involving diabetes and type and amount of carbohydrate. Although the relationship between blood glucose and insulin is linear, not all types of carbohydrate are fully metabolized to blood glucose. Added sugars such as sucrose and high fructose corn syrup are digested, absorbed, and fully metabolized in a similar fashion to naturally occurring mono- and disaccharides. Only about half of the carbohydrate grams from sugar alcohols and half or less from dietary fiber are metabolized to glucose whereas almost all "other carbohydrate" (mainly starch such as amylose and amylopectin) becomes blood glucose. The percent of energy as carbohydrate indicated for people with diabetes depends on individual preference, diabetes medication, and weight management goals. Glycemic index/glycemic load concepts are attempts to use these carbohydrate availability and amount issues for controlling postprandial glycemia.
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http://dx.doi.org/10.1016/j.jada.2008.01.024 | DOI Listing |
Pharmacoecon Open
January 2025
HTA & Pharmaceutical Economics Department, Italian Medicines Agency (AIFA), Rome, Italy.
Background: The authorization of new therapeutic indications for drugs already reimbursed by the Italian National Health Service (NHS) represents a matter of importance. This study aims to estimate the additional discount attributed to the extension of indications (EoIs) to explore the potential correlation between spending and negotiated discounts and to find specific factors (determinants) that impact on discount.
Methods: The study focused on drugs approved in Italy between 2003 and 2017 with at least four therapeutic indications, including the first approved and EoIs, with follow-up extended until 2021 to acquire all the information on the negotiation process that has been completed.
Angew Chem Int Ed Engl
January 2025
Nanjing University, College of Engineering and Applied Sciences, No. 163 Xianlin Avenue, Qixia District, Nanjing, Nanjing, CHINA.
Electrolyte engineering has emerged as an effective strategy for stabilizing Zn-metal anodes. However, a single solute or solvent additive is far from sufficient to meet the requirements for electrolyte cycling stability. Here, we report a new-type high-entropy electrolyte composed of equal molar amounts of Zn(OTf)2 and LiOTf, along with equal volumes of H2O, triethyl phosphate, and dimethyl sulfoxide, which enhances electrolyte stability by increasing solvation entropy.
View Article and Find Full Text PDFOphthalmic Epidemiol
January 2025
Vision Center of Excellence, Research and Engineering, Defense Health Agency, Bethesda, MD, USA.
Purpose: To evaluate the incidence, refractive error (RE) association, and distribution of atraumatic rhegmatogenous retinal detachment (RRD) in U.S. military service members (SMs).
View Article and Find Full Text PDFJ Acoust Soc Am
January 2025
USC Viterbi School of Engineering, University of Southern California, Los Angeles, California 90089-1455, USA.
Voice quality serves as a rich source of information about speakers, providing listeners with impressions of identity, emotional state, age, sex, reproductive fitness, and other biologically and socially salient characteristics. Understanding how this information is transmitted, accessed, and exploited requires knowledge of the psychoacoustic dimensions along which voices vary, an area that remains largely unexplored. Recent studies of English speakers have shown that two factors related to speaker size and arousal consistently emerge as the most important determinants of quality, regardless of who is speaking.
View Article and Find Full Text PDFMany cellular functions depend on the physical properties of the cell's environment. Many bacteria have different types of surface appendages to enable adhesion and motion on various surfaces. is a social soil bacterium with two distinctly regulated modes of surface motility, termed the social motility mode, driven by type IV pili, and the adventurous motility mode, based on focal adhesion complexes.
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