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[Lung carcinoma with paraneoplastic hyponatremia and hypercalcemia].
Med Pregl
May 2011
Klinika za internu medicinu, Odeljenje pulmologije, Klinicko bolnicki centar Bezanijska kosa, Beograd.
Introduction: Among the numerous paraneoplastic syndromes of the lung carcinoma, metabolic manifestations are of the particular clinical relevance. They are the consequence the prominent neurosecretory activity of certain peptides and hormones, mostly within amine precursor uptake and decarboxylation (APUD) secretion. Small cell lung carcinoma is the most common cause of paraneoplastic syndromes.
View Article and Find Full Text PDFArginine vasopressin, fluid balance and exercise: is exercise-associated hyponatraemia a disorder of arginine vasopressin secretion?
Sports Med
June 2010
Exercise Science Program, School of Health Sciences, Oakland University, Rochester, Michigan 48309, USA.
The ability of the human body to regulate plasma osmolality (POsm) within a very narrow and well defined physiological range underscores the vital importance of preserving water and sodium balance at rest and during exercise. The principle endocrine regulator of whole body fluid homeostasis is the posterior pituitary hormone, arginine vasopressin (AVP). Inappropriate AVP secretion may perpetuate either slow or rapid violation of these biological boundaries, thereby promoting pathophysiology, morbidity and occasional mortality.
View Article and Find Full Text PDFRenal effects of fresh water-induced hypo-osmolality in a marine adapted seal.
J Comp Physiol B
May 2002
A316 Earth and Marine Sciences, Department of Biology, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.
With few exceptions, marine mammals are not exposed to fresh water; however quantifying the endocrine and renal responses of a marine-adapted mammal to the infusion of fresh water could provide insight on the evolutionary adaptation of kidney function and on the renal capabilities of these mammals. Therefore, renal function and hormonal changes associated with fresh water-induced diuresis were examined in four, fasting northern elephant seal ( Mirounga angustirostris) (NES) pups. A series of plasma samples and 24-h urine voids were collected prior to (control) and after the infusion of water.
View Article and Find Full Text PDFWater metabolism disturbances at different stages of primary thyroid failure.
J Endocrinol
March 2001
Department of Endocrinology, Hospital Princeps d'Espanya, Ciutat Sanitària i Universitària de Bellvitge, Barcelona, Spain.
The aim of the present study was to study salt and water metabolism in thyroid deficiency. We performed an oral water loading test (OWL) and a hypertonic 5% saline infusion test (HSI) in 16 patients with overt primary hypothyroidism before replacement treatment (PRE group) and after, in eight patients with subclinical hypothyroidism (SUB group) and in 16 normal individuals (CG group). In the PRE group, a lower free water clearance was detected in the OWL (P < 0.
View Article and Find Full Text PDFEffects of an oral vasopressin receptor antagonist (OPC-31260) in a dog with syndrome of inappropriate secretion of antidiuretic hormone.
Aust Vet J
December 2000
Veterinary Clinic and Hospital, University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030.
Objective: The syndrome of inappropriate secretion of antidiuretic hormone is a rare disorder in dogs characterised by hypo-osmolality and persistent arginine vasopressin production in the absence of hypovolaemia and/or hypotension. The study describes the efficacy and safety of the nonpeptide selective arginine vasopressin V2 receptor antagonist OPC-31260 in a dog with the naturally occurring syndrome.
Design: The detailed case history of a dog with spontaneous syndrome of inappropriate secretion of antidiuretic hormone that received long-term therapy with oral OPC-31260 is presented.
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