AI Article Synopsis
- The study focuses on a new biodegradable polyester called poly(tetraethylene glycol succinate) (PTEGSuc), created by combining tetraethylene glycol and succinic acid with a catalyst.
- It was discovered that PTEGSuc can form micelles in water and its aggregation is sensitive to temperature, with the ability to control critical aggregation temperatures based on solution concentration.
- Transmission electron microscopy revealed that PTEGSuc micelles maintain a round shape, varying with solvent type, highlighting its potential applications in drug delivery, tissue engineering, and other medical devices.
Article Abstract
Amphiphilic biodegradable polyester, poly(tetraethylene glycol succinate) (PTEGSuc), was synthesized via melt polycondensation of tetraethylene glycol and succinic acid on catalysis of p-toluenesulfonic acid. It was observed that PTEGSuc could self-assemble into micelles in water. In addition, thermosensitivity of PTEGSuc aggregation in water was first found in the experiment, and the critical aggregation temperatures could be controlled by solution concentration. Transmission electron microscopy was used to investigate the micellar morphologies of PTEGSuc in different solvents. It was found that particle shape is almost round although the micellar morphology is different depending on the solvent used. Based on the perfect properties, especially in micelle formation and thermosensitivity, PTEGSuc is promising in biomedical field as carrier of drug delivery system, scaffold of tissue engineering, and other medical devices.
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| http://dx.doi.org/10.1002/jbm.a.31909 | DOI Listing |
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