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Peripheral endocannabinoid system activity in patients treated with sibutramine. | LitMetric

AI Article Synopsis

  • The study aimed to understand how the endocannabinoid system (ECS) affects weight gain and obesity, particularly focusing on the impact of the weight loss drug sibutramine on this system.
  • Twenty obese patients participated in a double-blind trial where they alternated between placebo and sibutramine, leading to a significant weight loss over 12 weeks without changes in endocannabinoid levels or gene expression.
  • The results suggest that while obesity activates the ECS, weight loss from sibutramine does not alter ECS components, implying that ECS dysregulation may contribute to obesity rather than being a result of it.

Article Abstract

Objective: The endocannabinoid system (ECS) promotes weight gain and obesity-associated metabolic changes. Weight loss interventions may influence obesity-associated risk indirectly through modulation of the peripheral ECS. We investigated the effect of acute and chronic treatment with sibutramine on components of the peripheral ECS.

Methods And Procedures: Twenty obese otherwise healthy patients received randomized, double-blind, crossover treatment with placebo and 15 mg/day sibutramine for 5 days each, followed by 12 weeks open-label sibutramine treatment. We determined circulating anandamide and 2-arachidonoylglycerol and expression levels of endocannabinoid genes in subcutaneous abdominal adipose tissue biopsies.

Results: Body weight was stable during the acute treatment period and decreased by 6.0+/-0.8 kg in those patients completing 3 months of sibutramine treatment (P<0.05). Circulating endocannabinoids and the expression of ECS genes did not change with acute or chronic sibutramine treatment.

Discussion: The ECS is activated in obesity. We did not find any influence of 5% body weight loss induced by sibutramine on circulating levels of endocannabinoids and adipose-tissue expression of endocannabinoid genes in obese subjects. These data confirm our previous findings on dietary weight loss and suggest that the dysregulation of the ECS may be a cause rather than a consequence of obesity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527586PMC
http://dx.doi.org/10.1038/oby.2008.47DOI Listing

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