The blood concentrations of various inflammatory reactants were studied in female participants of the in-vitro fertilization (IVF) programs depending on the outcome. Comparison of the obtained values with the values characteristic of healthy women and with the levels of the above reactants in patients with subacute inflammatory diseases of the uterine appendages indicated that females with IVF failures had elevated levels of lactoferrin and circulating alpha2-macroglobulin-IgG complexes and decreased concentrations of IgG as in women with a localized pyodestructive process in the appendages, but in women having effective IVF, the levels of the study proteins did not differ from those in healthy donors. The authors recommend that the above indices should be used as criteria substantiating the need for additional sanitation and anti-inflammatory therapy before initiating the IVF program.
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