The standard aspheric surface definition has been used successfully to correct aberrations in a wide variety of systems. However, in some current applications a more general surface definition is needed. We present a more general approach that uses parametrically defined optical surfaces for the optical design of imaging and illumination systems.
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http://dx.doi.org/10.1364/ao.39.005205 | DOI Listing |
ACS Appl Bio Mater
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.
Cuproptosis exhibits enormous application prospects in treatment. However, cuproptosis-based therapy is impeded by the limited intracellular copper ions, the nonspecific delivery, uncontrollable release, and chelation of endogenous overproduced glutathione (GSH). In this work, an ultrasound-triggered nanosonosensitizer (p-TiO-Cu(I)) was constructed for Cu(I) delivery, on-demand release, GSH consumption, and deeper tissue response.
View Article and Find Full Text PDFJAMA Ophthalmol
January 2025
John A. Moran Eye Center, Department of Ophthalmology & Visual Sciences, Department of Neurology, University of Utah Health, Salt Lake City.
Importance: Nearly 2% of the US population received a prescription for semaglutide in 2023. There has been a recent concern that this drug and other similar medications may be associated with ophthalmic complications.
Objective: To report ophthalmic complications associated with the use of semaglutide or tirzepatide.
Jpn J Ophthalmol
January 2025
Department of Ophthalmology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya Koshigaya, Saitama, 343-8555, Japan.
Purpose: To compare the amplitudes and implicit times of the oscillatory (OPs) of the full-field electroretinograms (ERGs) to those of the 30 Hz flicker ERGs in differentiating eyes with diabetic retinopathy (DR) from normal eyes.
Study Design: Single-center observational study.
Methods: Full-field ERGs were recorded in 55 patients with Type 2 diabetes mellitus (DM) and 20 normal control subjects.
ASN Neuro
January 2025
Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, USA.
Despite tremendous progress in characterizing the myriad cellular structures in the nervous system, a full appreciation of the interdependent and intricate interactions between these structures is as yet unfulfilled. Indeed, few more so than the interaction between the myelin internode and its ensheathed axon. More than a half-century after the ultrastructural characterization of this axomyelin unit, we lack a reliable understanding of the physiological properties, the significance and consequence of pathobiological processes, and the means to gauge success or failure of interventions designed to mitigate disease.
View Article and Find Full Text PDFRev Sci Instrum
January 2025
Department of Plasma Physics and Fusion Engineering, University of Science and Technology of China, Hefei 230026, China.
A novel all-fiber optic current sensor (FOCS) is designed specifically for the measurement of large transient currents based on the Faraday effect. A reciprocal symmetric structure is incorporated into the optical sensing loop, and the current dependent phase demodulation is achieved by using a passive optical fiber coupler and the homodyne detection scheme. This design offers several advantages, including structural simplicity, high voltage insulation, low noise, high linearity, and excellent frequency response, and is highly suitable for use in any system of high-voltage, high-power, and high-frequency in nature.
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