The treatment of human skin fibroblasts with hyaluronidase stimulated the activity of hyaluronate synthase and the amount of hyaluronate secreted into the medium increased with the concentration of the enzyme and the time of the treatment. The maximal increase (about 3 fold) was independent of the type of glycosidic linkage cleaved, was inhibited neither by hyaluronate nor by oligosaccharides from hyaluronate and decreased in the late passage cultures. The increased hyaluronate synthesis was parallelled by 40% stimulation of the proliferation of fibroblasts up to 24th cell passage. The 10% stimulation of cell growth in late (36th passage) indicates a decrease in the ability of fibroblasts to respond to the degradation of the pericellular hyaluronate with in vitro ageing.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The role of ultrasound in facial hyaluronic acid dermal filler injections - A review article.
Clin Imaging
January 2025
Department of Radiological Sciences, Ultrasound Program, Princess Nourah Bint Abdulrahman University. Electronic address:
Injectable dermal fillers have seen a remarkable rise in popularity in recent years for aesthetic enhancements, such as facial contouring and rejuvenation. Hyaluronic acid (HA)-based fillers are especially favored due to their tolerability, minimal invasiveness, and effectiveness. This review examines the applications of ultrasound in HA dermal filler procedures.
View Article and Find Full Text PDFOn-demand celastrol delivery by hyaluronic acid-porphyrinic metal-organic frameworks for synergistic sonodynamic/pharmacological antibacterial therapy.
Int J Biol Macromol
January 2025
Institute of urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science &Technology Center, Chengdu 610213, China; School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China. Electronic address:
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent bacterial pathogens. The multi-drug resistance and strong biofilm-forming ability make the treatment of MRSA infections challenging. It is urgent to develop antibiotic-free, noninvasive and effective strategies against MRSA infections.
View Article and Find Full Text PDFCarbohydrate polymer-based nanoparticles in curcumin delivery for cancer therapy: A review.
Int J Biol Macromol
January 2025
Precision Medicine Center, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. Electronic address:
The use of natural products for cancer treatment has a lengthy history. The safety and multifunctionality of naturally occurring substances have rendered them appropriate for cancer treatment. Curcumin influences multiple molecular pathways and is advantageous for treating both hematological and solid tumors.
View Article and Find Full Text PDFThiol-modified hyaluronic acid and hydroxyl radical-induced oxidation synergistically enhance the gelling capacity of ginkgo seed proteins.
Food Chem
January 2025
Department of Food Science and Engineering, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
The objective of this work was to investigate the effect of synthetic thiol-modified hyaluronic acid (HASH) on the gelation properties of ginkgo seed protein isolate (GSPI) under non-oxidizing (NOX) or oxidizing (OX) conditions. Under NOX conditions, HASH mediated the disruption of disulfide bonds, leading to a dose-dependent dissociation of GSPI. Conversely, in OX conditions, hydroxyl radical-induced oxidation facilitated the formation of interprotein disulfide bonds.
View Article and Find Full Text PDFNew N-Alkylketonetetrahydroisoquinoline derivatives exhibits antitumor effect by HA-CD44 interaction inhibition in MDA-MB-231 breast cancer.
Bioorg Chem
January 2025
Department of Medicinal and Organic Chemistry and Excellence Research Unit of Chemistry Applied to Biomedicine and the Environment, Faculty of Pharmacy, University of Granada, Campus Cartuja s/n 18071 Granada, Spain; Biosanitary Institute of Granada (ibs.GRANADA), SAS-University of Granada, Avenida de Madrid, 15 18012 Granada, Spain. Electronic address:
Molecular interactions at the cell surface, in particular between hyaluronic acid (HA) and the cluster of differentiation 44 (CD44) receptor, are crucial in several biological processes and diseases such as cancer. Thus, inhibition of the HA-CD44 interaction has become a promising therapeutic strategy. Etoposide was the only antitumor compound known to inhibit the binding of CD44 to HA, thereby disrupting key functions that drive malignancy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!