Antipsychotic-induced hyperprolactinemia and delusion of pregnancy.

Psychosomatics

Northumberland, Tyne and Wear NHS Trust, UK.

Published: April 2008

The authors describe 12 patients with antipsychotic-induced hyperprolactinemia. Six patients had erroneous ideas of being pregnant (four delusional and two non-delusional) temporally associated with hyperprolactinemia and resolving as prolactin levels returned to normal. The remaining six patients did not develop such ideas. Contrasting the clinical features of the two groups of patients in the context of existing literature informs on the possible biological and cognitive mechanisms that can be hypothesized to underlie the relationship between hyperprolactinemia due to antipsychotics and the development of inaccurate beliefs and feelings about pregnancy, and the effect of current mental state on the propensity to develop these beliefs.

Download full-text PDF

Source
http://dx.doi.org/10.1176/appi.psy.49.2.163DOI Listing

Publication Analysis

Top Keywords

antipsychotic-induced hyperprolactinemia
8
hyperprolactinemia delusion
4
delusion pregnancy
4
pregnancy authors
4
authors describe
4
patients
4
describe patients
4
patients antipsychotic-induced
4
hyperprolactinemia patients
4
patients erroneous
4

Similar Publications

Article Synopsis
  • * This study used network pharmacology and molecular docking techniques to identify molecular targets of aripiprazole and how they relate to hyperprolactinemia, finding 27 common genes and establishing a protein-protein interaction network.
  • * Key proteins that aripiprazole targets include SLC6A3, MAO-B, DRD2, HTR2A, and HTR2C, which were analyzed further to understand their roles in treating
View Article and Find Full Text PDF

Objective: This study aims to compare the risks of different antipsychotics in causing hyperprolactinemia, taking into account the age, gender, and onset time.

Materials And Methods: We searched the FDA Adverse Event Reporting System (FAERS) from January 1, 2004, to March 31, 2022, for reports of hyperprolactinemia treated with antipsychotics. We evaluated the association between antipsychotics and the risk of hyperprolactinemia using reporting odds ratio (ROR) based on a disproportionality analysis.

View Article and Find Full Text PDF

Treatment of antipsychotic-induced hyperprolactinemia: an umbrella review of systematic reviews and meta-analyses.

Front Psychiatry

March 2024

The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, Beijing, China.

Background: Hyperprolactinemia is a common antipsychotic-induced adverse event in psychiatric patients, and the quality of clinical studies investigating the best treatments has varied. Thus, to better summarize the clinical evidence, we performed an umbrella review of overlapping systematic reviews and meta-analyses for the treatment of antipsychotic-induced hyperprolactinemia.

Methods: The PubMed, Cochrane Library, PsycINFO, Scopus and EMBASE were searched, and reviews and meta-analyses meeting our inclusion criteria were selected.

View Article and Find Full Text PDF

Background: Hyperprolactinemia is a commonly underestimated adverse effect of antipsychotic medications. There are still no consensus guidelines for the optimal monitoring and treatment strategies.

Objective: The aim of the study was to assess the monitoring and treatment practices of antipsychotic-induced hyperprolactinemia, in addition to the prevalence and risk factors associated with it.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!