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Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice.
J Clin Invest
December 2024
Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, United States of America.
Vitamin D regulates mineral homeostasis. The most biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), is synthesized by CYP27B1 from 25-dihydroxyvitamin D (25D) and inactivated by CYP24A1. Human monogenic diseases and genome-wide association studies support a critical role for CYP24A1 in regulation of mineral homeostasis, but little is known about its tissue-specific effects.
View Article and Find Full Text PDFImpact of adolescents' binge drinking on blood chemistry.
Eur J Pediatr
December 2024
Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Della Commenda 9, 20122, Milan, Italy.
Article Synopsis
- - The study examined the effects of binge drinking on adolescent blood chemistry, focusing on glucose, sodium, calcium, potassium, and acid-base balance, by analyzing medical records from 173 teenagers treated at a Milan hospital between 2013 and 2023.
- - Results showed that while glucose, sodium, and calcium levels were generally stable, there were significant cases of hypokalemia and an overwhelming presence of acute respiratory acidosis among binge drinkers.
- - The findings indicate that binge drinking in adolescents leads to notable disturbances in acid-base balance and potassium levels, but has little impact on glucose, sodium, and calcium levels.
Clinical, Biochemical, and Histological Manifestations and Long-Term Outcomes of Renal Sarcoidosis - A Single Center Study.
Indian J Nephrol
July 2024
Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Background: Renal involvement in sarcoidosis is rare. We evaluated the pattern of renal involvement in sarcoidosis, its clinical course, renal histology, and response to treatment.
Materials And Methods: We retrospectively analyzed the data of all cases with sarcoidosis exhibiting renal involvement referred to our department between January 2010 and December 2021.
Severe, Symptomatic Hypercalcemia Secondary to PTH-secreting Pancreatoblastoma.
JCEM Case Rep
December 2024
Division of Organ Transplantation, Scripps Green Hospital, La Jolla, CA 92037, USA.
Hypercalcemia may be induced by a variety of etiologies, most commonly primary hyperparathyroidism. Although primary hyperparathyroidism represents a relatively common endocrinological disorder, ectopic PTH secretion is a rare entity that is less well described in literature. We describe the first case to our knowledge of severe, symptomatic hypercalcemia found to be secondary to a PTH-secreting pancreatoblastoma.
View Article and Find Full Text PDFSingle zoledronic acid infusion as a cause of acute kidney impairment requiring dialysis in two patients with osteoporosis.
Arch Endocrinol Metab
November 2024
Department of Endocrinology Copenhagen Denmark Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark.
Article Synopsis
- * Although generally safe, reports indicate acute kidney impairment can occur, particularly in patients with cancer or preexisting kidney issues after high doses.
- * This report presents two cases of low-risk patients who developed severe kidney impairment requiring dialysis after a single dose of zoledronic acid, emphasizing the importance of monitoring kidney function in all recipients of the drug.
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