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Deep Fungal Infections of Skin and Role of Histopathology in Diagnosis.
Indian J Dermatol
October 2024
Department of Dermatology, Institute of Child Health, Kolkata, India.
Introduction: Deep mycoses acquired by penetrating trauma to the skin can have varied and sometimes atypical morphological presentations resulting in diagnostic dilemmas and delay in treatment onset. Histopathology can be a useful tool in not only diagnosing but also differentiating various deep mycoses.
Aims And Objectives: To observe various morphological presentations and histopathological features of deep fungal infections.
Primary cutaneous cryptococcosis - History, concepts, clinical and therapeutic update.
An Bras Dermatol
November 2024
Department of Infectology, Dermatology, Diagnostic Imaging and Radiotherapy, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Cryptococcosis is a disease caused by fungi of the genus Cryptococcus, with the species Cryptococcus neoformans and Cryptococcus gattii being recognized as pathogenic. Cutaneous cryptococcosis can be classified as "secondary", developing from a previous systemic disease, or, on the contrary, "primary", resulting from transcutaneous inoculation of the agent. It can also be classified as "disseminated cutaneous cryptococcosis", when there is an associated systemic disease, or "localized", when it is restricted to the skin.
View Article and Find Full Text PDFFrom Histoplasmosis to Cryptococcosis: A diagnostic journey of pediatric scalp abscess.
Indian J Med Microbiol
December 2024
Department of Microbiology, All India Institute of Medical Sciences, Bhubaneswar, 751019, India. Electronic address:
Article Synopsis
- A 3-year-old boy undergoing treatment for disseminated tuberculosis developed scalp swelling, prompting a needle aspirate.
- The aspirate identified yeasts inside macrophages, initially misdiagnosed as Histoplasmosis but later confirmed as Cryptococcosis.
- Treatment with liposomal amphotericin B and fluconazole led to the resolution of lesions, marking this as a rare pediatric case of cryptococcosis from Odisha.
Concurrent Primary Cutaneous Cryptococcosis and Bowen's Disease in a Patient With Multiple Sclerosis on Fingolimod: A Rare Case Report and Review of Literature.
Cureus
October 2024
Department of Dermatology, Bezmialem Vakif University Faculty of Medicine, Istanbul, TUR.
Fingolimod is an oral disease-modifying treatment used for the relapsing-remitting forms of multiple sclerosis, which may render patients susceptible to opportunistic infections and lead to an increased risk of skin cancer. We report a 56-year-old woman with multiple sclerosis in remission on fingolimod treatment for five years presenting with the following skin lesions. Our patient presented with a non-healing ulcerated erythematous lesion on the left lower abdomen for six months and a crusted erythematous plaque on the forehead that had not healed for one year.
View Article and Find Full Text PDF3D Printable Alginate-Chitosan Hydrogel Loaded With Ketoconazole Exhibits Anticryptococcal Activity.
Biopolymers
January 2025
Laboratório de Biomateriais Poliméricos (Poli-BIO), Instituto de Química, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Natural polymers have recently been investigated for various applications, such as 3D printing and healthcare, including treating infections. Among microbial infections, fungal diseases remain overlooked, with limited therapeutic options and high recurrence. Cutaneous cryptococcosis is an opportunistic fungal infection triggered by mechanical inoculation or hematogenous dissemination of the yeast that causes cryptococcal pneumonia and meningitis.
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