Background: Hyperventilation symptoms are among the sensations asthma patients tend to report during exacerbations of their disease. However, little is known about their importance for the patients' perceived well-being.
Method: We therefore studied the association of reported hyperventilation symptoms (Asthma Symptom Checklist) with perceived physical and mental health (36-item Short-form Health Survey) in a sample of primary care asthma patients (N = 190). We also studied the potential role of perceived control of asthma (Perceived Control of Asthma Questionnaire) in mediating any association between these variables.
Results: In hierarchical multiple regression analyses controlling for demographics, asthma severity, and other asthma symptoms (obstruction, congestion, panic-fear, irritation, and fatigue), hyperventilation symptoms were significantly associated with both physical and mental health status. This association was partially mediated by perceived control of asthma.
Conclusion: It is possible that hypocapnia creates symptoms that asthma patients cannot control by using their antiasthmatic medication, thus compromising their perceived control over the management of their asthma, and consequently their perceived health. Behavioral interventions should address the problem of hyperventilation in asthma.
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http://dx.doi.org/10.1007/s12160-007-9014-7 | DOI Listing |
Background: Unexplained exertional dyspnoea without significant elevation of natriuretic peptides is common. One of the causes might be early heart failure with preserved ejection fraction (HFpEF).
Aims: This study aimed to characterize patients with exertional dyspnoea and normal/near-to-normal N-terminal pro-brain natriuretic peptide (NT-proBNP) levels with regard to early stages of HFpEF and non-cardiac causes.
Biomedicines
December 2024
Department of Pediatric Anesthesiology and Intensive Therapy, Medical University of Warsaw, 02-091 Warsaw, Poland.
Epstein-Barr virus (EBV) usually causes mild, self-limiting, or asymptomatic infection in children, typically infectious mononucleosis. The severe course is more common in immunocompromised patients. Neurological complications of primary infection, reactivation of the latent infection, or immune-mediated are well-documented.
View Article and Find Full Text PDFPLoS Comput Biol
December 2024
Human Science Research-Domain, Toyota Central R&D Labs., Inc., Nagakute, Japan.
Voluntary breathing (VB), short-term exercise (STE), and mental stress (MS) can modulate breathing rate (BR), heart rate (HR), and blood pressure (BP), thereby affecting human physical and mental state. While existing experimental studies have explored the relationship between VB, STE, or MS and BR, HR, and BP changes, their findings remain fragmented due to individual differences and challenges in simultaneous, BR, HR, and BP measurements. We propose a computational approach for in-silico simultaneous measurements of the physiological values by comprehensive prediction of the respiratory and circulatory system responses to VB, STE, or MS.
View Article and Find Full Text PDFFront Neurosci
November 2024
Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.
Purpose: Reflex syncope is a burdensome disease with considerable repercussions on the quality of life. Tilt training is a therapeutic option, but evidence on this topic is scarce and outdated. Hyperventilation is oftentimes associated with reflex syncope.
View Article and Find Full Text PDFInt J Biol Sci
December 2024
State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China.
During cortical development, the differentiation potential of neural progenitor cells (NPCs) is one of the most critical steps in normal cortical formation and function. Defects in this process can lead to many brain disorders. MicroRNA dysregulation in the dorsolateral prefrontal cortex is associated with risk for a variety of developmental and psychiatric conditions.
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