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Retro-age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements.
Aging Cell
October 2024
Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York City, USA.
Reactivation of retroelements in the human genome has been linked to aging. However, whether the epigenetic state of specific retroelements can predict chronological age remains unknown. We provide evidence that locus-specific retroelement DNA methylation can be used to create retroelement-based epigenetic clocks that accurately measure chronological age in the immune system, across human tissues, and pan-mammalian species.
View Article and Find Full Text PDFLithium response in bipolar disorder: Epigenome-wide DNA methylation signatures and epigenetic aging.
Eur Neuropsychopharmacol
August 2024
Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Spain; CIBER de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
Article Synopsis
- * A study compared DNA methylation profiles between excellent responders to Li and non-responders, identifying 130 differentially methylated positions and linking them to several genes associated with Li response, particularly in the GSK3β pathway.
- * Despite finding a specific methylation pattern that may predict Li response, no significant differences in age acceleration were observed between responders and non-responders, suggesting more research is needed to explore the underlying mechanisms.
RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer.
Clin Cancer Res
April 2024
Dana-Farber Brigham and Women's Cancer Center, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
Purpose: ERBB2-amplified colorectal cancer is a distinct molecular subtype with expanding treatments. Implications of concurrent oncogenic RAS/RAF alterations are not known.
Experimental Design: Dana-Farber and Foundation Medicine Inc.
Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states.
bioRxiv
December 2023
Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York City, New York, USA.
Human endogenous retroviruses (HERVs), the remnants of ancient viral infections embedded within the human genome, and long interspersed nuclear elements 1 (LINE-1), a class of autonomous retrotransposons, are silenced by host epigenetic mechanisms including DNA methylation. The resurrection of particular retroelements has been linked to biological aging. Whether the DNA methylation states of locus specific HERVs and LINEs can be used as a biomarker of chronological age in humans remains unclear.
View Article and Find Full Text PDFCell-type specific impact of metformin on monocyte epigenetic age reversal in virally suppressed older people living with HIV.
Aging Cell
January 2024
Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York City, New York, USA.
The anti-diabetic drug metformin may promote healthy aging. However, few clinical trials of metformin assessing biomarkers of aging have been completed. In this communication, we retrospectively examined the effect of metformin on epigenetic age using principal component (PC)-based epigenetic clocks, mitotic clocks, and pace of aging in peripheral monocytes and CD8 T cells from participants in two clinical trials of virologically-suppressed people living with HIV (PLWH) with normal glucose receiving metformin.
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