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Advanced thyroid nodule detection using ultrasonography image analysis and bilateral mean clustering strategies.
Comput Biol Med
January 2025
Department of Computing Technologies, School of Computing, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India. Electronic address:
This research work focuses on developing an advanced diagnostic method for thyroid nodules using ultrasonography images. The core idea revolves around the observation that the presence and amount of calcium flecks in thyroid nodules can indicate their severity, potentially leading to severe thyroid cancer. A novel technique, named Bilateral Mean Clustering Strategy (Bi-MCS), is proposed, combining the strengths of Fuzzy C mean and K-mean clustering approaches.
View Article and Find Full Text PDFIntroduction: Differentiated thyroid cancer (DTC) is the most common type of endocrine malignancy, with rising incidence over recent decades. Despite a favorable prognosis, DTC management remains complex, often involving thyroidectomy followed by radioactive iodine (RAI) therapy. While RAI is crucial for patient outcomes, its efficacy varies, necessitating the identification of predictors for treatment response.
View Article and Find Full Text PDFMachine learning applications in healthcare clinical practice and research.
World J Clin Cases
January 2025
Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, Athens 11527, Greece.
Machine learning (ML) is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis, thus creating machines that can complete tasks otherwise requiring human intelligence. Among its various applications, it has proven groundbreaking in healthcare as well, both in clinical practice and research. In this editorial, we succinctly introduce ML applications and present a study, featured in the latest issue of the .
View Article and Find Full Text PDFSarcopenia as a Prognostic Factor and Multimodal Interventions in Breast Cancer.
Int J Gen Med
December 2024
Department of Thyroid and Breast Surgery, Quzhou People's Hospital, Quzhou, 324000, People's Republic of China.
Objective: This study aims to demonstrate the impact of sarcopenia on the prognosis of early breast cancer and its role in early multimodal intervention.
Methods: The clinical data of patients (n=285) subjected to chemotherapy for early-stage breast cancer diagnosed pathologically between January 1, 2016, and December 31, 2020, in our hospital were retrospectively analyzed. Accordingly, the recruited subjects were divided into sarcopenia (n=85) and non-sarcopenia (n=200) groups according to CT diagnosis correlating with single-factor and multifactorial logistic regression analyses.
The right drug for the right patient at the right time with the right test in differentiated thyroid cancer (DTC).
J Clin Transl Endocrinol
December 2024
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40138 Bologna, Italy.
Thanks to the identification of crucial molecular pathways, the therapeutic landscape for advanced differentiated thyroid tumors (DTCs) has significantly improved during the last ten years. The therapeutic scenario has been greatly impacted by the discovery of mutually exclusive gene changes in the MAPK and PI3K/AKT pathways, such as or fusions and pathogenic mutations of the and genes. Indeed, multi-kinase inhibitors and selective inhibitors have demonstrated outstanding efficacy for radioactive iodine-refractory (RAI-R) drug treatment, with overall response rates reaching up to 86%.
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