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Chemotherapeutic potential of radotinib against blood and solid tumors: A beacon of hope in drug repurposing.
Bioorg Chem
January 2025
Molecular Toxicology Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641046, India. Electronic address:
Tyrosine kinase inhibitors (TKIs) represent a pivotal class of targeted therapies in oncology, with multiple generations developed to address diverse molecular targets. Imatinib is the first TKI developed to target the BCR-ABL1 chimeric protein, which is the key driver oncogene implicated in Philadelphia chromosome-positive chronic myeloid leukemia (CML). Several second-generation tyrosine kinase inhibitors (2GTKIs), such as nilotinib, dasatinib, bosutinib, and radotinib (RTB), followed the groundbreaking introduction of imatinib.
View Article and Find Full Text PDFChiral Differentiation of Chiral Lactides and Chiral Diketones on Native and Phenylcarbamoylated Cyclodextrin Chiral Stationary Phases.
Chirality
December 2024
School of Science, Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin University, Tianjin, China.
Inclusion complexation, hydrogen bonds, π-π interaction, dipole-dipole interaction, and steric hindrance effect all contribute to the enantioseparation ability of cyclodextrin (CD) or CD derivatives. In this work, one native cationic CD chiral stationary phases (SHCDCSP) and four derivatized CD-CSPs, namely, per(4-trifluoromethyl) phenylcarbamoylated-β-CD CSP (SFPhCDCSP), per(4-chloro) phenylcarbamoylated-β-CD CSP (SCPhCDCSP), per(4-bromo) phenylcarbamoylated-β-CD CSP (SBPhCDCSP), and per(4-methyl) phenylcarbamoylated-β-CD CSP (SMPhCDCSP), were prepared via thioether linkage and applied for the enantioseparation of chiral lactides and chiral diketones in both reverse phase (RP) and normal phase (NP) modes. Most of the studied chiral lactides were found to be well resolved (R > 1.
View Article and Find Full Text PDFSynthesis, crystal structure and thermal properties of a new polymorphic modification of diiso-thio-cyanato-tetra-kis-(4-methyl-pyridine)cobalt(II).
Acta Crystallogr E Crystallogr Commun
May 2024
Institut für Anorganische Chemie, Universität Kiel, Germany.
The title compound, [Co(NCS)(CHN)] or Co(NCS)(4-methyl-pyridine), was prepared by the reaction of Co(NCS) with 4-methyl-pyridine in water and is isotypic to one of the polymorphs of Ni(NCS)(4-methyl-pyridine) [Kerr & Williams (1977 ▸). B, 3589-3592 and Soldatov (2004 ▸). , 1185-1194].
View Article and Find Full Text PDFSargassum spp. Ethanolic Extract Elicits Toxic Responses and Malformations in Zebrafish (Danio rerio) Embryos.
Environ Toxicol Chem
May 2024
Departamento de Recursos del Mar, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Unidad Mérida, Mérida, Yucatán, México.
The amount of Sargassum spp. arriving in the Caribbean Sea has increased steadily in the last few years, producing a profound environmental impact on the ecological dynamics of the coasts of the Yucatan Peninsula. We characterized the toxicological effects of an ethanolic extract of Sargassum spp.
View Article and Find Full Text PDFPhoto-driven water oxidation performed by supramolecular photocatalysts made of Ru(II) photosensitizers and catalysts.
J Chem Phys
February 2024
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, and Interuniversitary Research Center on Artificial Photosynthesis (SOLAR-CHEM, Messina Node), University of Messina, via F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Two new supramolecular photocatalysts made of covalently linked Ru(II) polypyridine chromophore subunits ([Ru(bpy)3]2+-type species; bpy = 2,2'-bipyridine) and [RuL(pic)2] (L = 2,2'-bipyridine-6,6'-dicarboxylic acid; pic = 4-picoline) water oxidation catalyst subunits have been prepared. The new species, 1 and 2, contain chromophore and catalyst subunits in the molecular ratios 1:1 and 1:2, respectively. The model chromophore species [Ru(bpy)2(L1)]2+ (RuP1; L1=4-[2-(4-pyridyl)-2-hydroxyethyl]-4-methyl-2,2'-bipyridine) and [Ru(bpy)2(L2)]2+ (RuP2; L2 = 4,4'-bis[2-(4-pyridyl)-2-hydroxyethyl]-2,2'-bipyridine) have also been prepared.
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