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Study Protocol for a Prospective, Unicentric, Double-Blind, Randomized, and Placebo-Controlled Trial on the Efficacy of a Low-Histamine Diet and DAO Enzyme Supplementation in Patients with Histamine Intolerance.
Nutrients
December 2024
Departament de Nutrició, Ciències de l'Alimentació i Gastronomia, Campus de l'Alimentació de Torribera, Universitat de Barcelona (UB), 08921 Santa Coloma de Gramenet, Spain.
Background/objectives: Histamine intolerance is primarily caused by a deficiency in the diamine oxidase (DAO) enzyme at the intestinal level. The reduced histamine degradation in the gut leads to its accumulation in plasma, thereby causing multiple clinical manifestations, such as urticaria, diarrhea, headache, dyspnea, or tachycardia, among others. The dietary management of this food intolerance consists of the follow-up of a low-histamine diet, often combined with DAO supplementation.
View Article and Find Full Text PDFExploration of molecular interactions responsible for anti-inflammatory attributes of GI friendly micro-sized formulation of flurbiprofen and clove oil.
Inflammopharmacology
January 2025
Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Punjab, 63100, Pakistan.
Clove oil obtained from Syzygium aromaticum (L.) is traditionally employed to treat inflammation associated with rheumatism, gastric disorders, and as an analgesic. Chemo-herbal combinations are known to have potent anti-inflammatory and analgesic effects, while mitigating the drug related side effects.
View Article and Find Full Text PDFBortezomib induces Rho-dependent hyperpermeability of endothelial cells synergistically with inflammatory mediators.
BMC Pulm Med
December 2024
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Background: Bortezomib (BTZ), a selective 26 S proteasome inhibitor, is clinically useful in treating multiple myeloma and mantle cell lymphoma. BTZ exerts its antitumor effect by suppressing nuclear factor-B in myeloma cells, promoting endothelial cell apoptosis, and inhibiting angiogenesis. Despite its success, pulmonary complications, such as capillary leak syndrome of the vascular hyperpermeability type, were reported prior to its approval.
View Article and Find Full Text PDFLoratadine Loaded Chitosan Tannic Acid Nanoparticles as Anti-Proliferative Agent Against Breast Cancer: In-silico, in-vitro and Cell Studies.
Int J Nanomedicine
November 2024
Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, 6th of October City, Giza, Egypt.
Purpose: This study aims to prepare Loratadine-loaded chitosan/tannic acid nanoparticles (LOR-CS/TAN NPs) through ionic gelation to be used as an anti-proliferative agent to aid in overcoming breast cancer propagation.
Methods: First, in-silico virtual screening was carried out to select the most appropriate anti-histaminic drug based on its inhibitory effect on the H1-histamine receptor, resulting in the selection of Loratadine (LOR). Molecular interaction between LOR with chitosan (CS), a positively charged polymer, and hyaluronan, a negatively charged polymer, was investigated separately through molecular docking, leading to the selection of CS.
Integration of pharmacochemistry, pharmacodynamics and metabolomics to reveal active ingredients and mechanism of Nan Bao detox capsule alleviating methamphetamine addiction.
Addict Biol
November 2024
Hunan Academy of Chinese Medicine, Changsha, China.
Article Synopsis
- Nan Bao detox capsule (NBDC) is based on ancient Chinese methods and shows potential in treating substance abuse, especially for methamphetamine addiction.
- The study identified key active ingredients in NBDC and tested its effects in a rat model, showing improvements in behavior and neurotransmitter levels, such as increased dopamine and serotonin.
- Metabolomic analysis highlighted the histamine receptor as a target and linked NBDC to metabolic pathways relevant to cocaine addiction and Parkinson's disease, suggesting its multi-faceted therapeutic action against methamphetamine addiction.
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