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Introduction: Patients with end-stage renal disease usually undergo hemodialysis as a way of renal function replacement therapy which comes with a wide array of systemic and cutaneous complications. The aim of this study was to evaluate the most frequent dermatological manifestations including xerosis, pruritis and other nail, hair and oral conditions, as these are a very important aspect to be considered while managing the patients psychological and physical needs to improve their outcomes and quality of life.

Methods: This retrospective cross-sectional study was performed by selecting 77 patients on hemodialysis based on a certain criteria and data was then collected on a sheet using patients database on Hakeem National E-Health Program, in addition to information from interviews with patients during their hemodialysis sessions after taking an oral informed consent and insuring patients' privacy.

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Cutaneous Manifestations of Liver Disease: A Narrative Review.

Cureus

September 2024

Internal Medicine, Centro Médico Nacional Siglo XXI, Mexico City, MEX.

Chronic liver disease is a major cause of morbidity and mortality. The most common extrahepatic manifestations are dermatological. The pathophysiology of these dermatological manifestations is not clear, but it is postulated that the mechanisms involved include generalized vasodilatation, hyperdynamic blood circulation, and altered estrogen metabolism.

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Article Synopsis
  • Telomere biology disorders (TBD) are inherited conditions linked to short telomeres, with dyskeratosis congenita (DC) being a severe phenotype characterized by various physical symptoms.
  • A case study details a 2-year-old girl with specific symptoms (reticulated pigmentary changes and Terry's nails) who was found to have a TERT gene variant and short telomeres, but did not show the full range of TBD features.
  • The report emphasizes the need for awareness and diagnosis of TBD, even in patients who exhibit only mild or limited symptoms of classic DC.
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