Beta-turn secondary structure and melanocortin ligands.

Bioorg Med Chem

Department of Medicinal Chemistry, University of Florida, PO Box 100485, Gainesville, FL 32610, USA.

Published: February 2009

The melanocortin pathway has emerged during this past decade as an important target area for the discovery and development of therapeutic agents related to obesity and type 2 diabetes. This peptide-G-protein coupled receptor (GPCR) pathway has evolved from peptide-based ligands to small molecules possessing a variety of different molecular scaffolds. Herein, we summarize the originating hypothesis of the importance of the reverse beta-turn secondary structure for agonist ligand potency at the melanocortin receptors and how that information was utilized for the discovery of small molecules based upon this type of turn structure.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662475PMC
http://dx.doi.org/10.1016/j.bmc.2008.02.090DOI Listing

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