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The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress.
Sci Rep
December 2024
Department of Psychiatry and Behavioral Sciences and Weill Center for Neurosciences, University of California, San Francisco, CA, 94107, USA.
Telomere attrition is a hallmark of biological aging, contributing to cellular replicative senescence. However, few studies have examined the determinants of telomere attrition in vivo in humans. Mitochondrial Health Index (MHI), a composite marker integrating mitochondrial energy-transformation capacity and content, may be one important mediator of telomere attrition, as it could impact telomerase activity, a direct regulator of telomere maintenance.
View Article and Find Full Text PDFPrognostic role of aetiological agent vs. clinical pattern in candidates to lead extraction for cardiac implantable electronic device infections.
Sci Rep
December 2024
Department of Medical and Surgical Sciences, Institute of Cardiology, University of Bologna, Policlinico S.Orsola-Malpighi, via Massarenti 9, Bologna, 40138, Italy.
Cardiac implantable electronic devices infections (CIEDI) are associated with poor survival despite the improvement in transvenous lead extraction (TLE). Aetiology and systemic involvement are driving factors of clinical outcomes. The aim of this study was to explore their contribute on overall mortality.
View Article and Find Full Text PDFPerceived Neighbourhood Walkability and Depressive Symptoms of Rural Older Adults in Urbanisation: The Role of Community-Based Social Capital.
J Community Psychol
January 2025
School of Humanities, Shanghai Institute of Technology, Shanghai, China.
This study aims to explore the association between community-based social capital, namely clan identity and sense of community (SOC), and perceived neighbourhood walkability (PNW) in relation to depressive symptoms among rural older adults in urbanisation. A sample of 489 older adults in an urbanising county of Western China participated and moderated mediation analysis was utilised. PNW was negatively associated with depressive symptoms, and SOC mediated the focal association.
View Article and Find Full Text PDFIncreased cell-free DNA in CSF and serum of hip fracture patients with delirium.
Brain Commun
December 2024
Oslo Center for Clinical Heart Research, Department of Cardiology Ullevaal, Oslo University Hospital, Oslo 0424, Norway.
Delirium is a neuropsychiatric syndrome commonly presenting during acute illness. The pathophysiology of delirium is unknown, but neuroinflammation is suggested to play a role. In this cross-sectional study, we aimed to investigate whether cell-free DNA and markers of neutrophil extracellular traps in serum and CSF were associated with delirium and neuronal damage, assessed by neurofilament light chain.
View Article and Find Full Text PDFAssociation between internet use and primary headache severity among Hungarian university students: a cross-sectional study.
Front Public Health
December 2024
Department of Ophtalmology, Medical School, University of Pécs, Pécs, Hungary.
Background: Recent studies suggest that increased digital technology usage could be a factor in the rising occurrence and severity of headache episodes. The purpose of this cross-sectional study was to determine whether the severity of primary headaches (migraine and tension-type headache) is associated with problematic internet use taking many covariates into account.
Methods: We conducted an online cross-sectional survey using a quantitative, descriptive questionnaire, targeting university students enrolled in correspondence courses, aged 18 to 65.
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