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Evaluation of Phoenix Sepsis Score Criteria: Exploratory Analysis of Characteristics and Outcomes in an Emergency Transport PICU Cohort From the United Kingdom, 2014-2016.
Pediatr Crit Care Med
January 2025
Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, United Kingdom.
Objectives: To assess characteristics and outcomes of children with suspected or confirmed infection requiring emergency transport and PICU admission and to explore the association between the 2024 Phoenix Sepsis Score (PSS) criteria and mortality.
Design: Retrospective analysis of curated data from a 2014-2016 multicenter cohort study.
Setting: PICU admission following emergency transport in South East England, United Kingdom, from April 2014 to December 2016.
Monocyte Anisocytosis is Associated with Sepsis in Children with Suspected Infection.
Shock
October 2024
Massachusetts General Hospital, Department of Pediatrics.
Background: Early, accurate determination of disease severity in an emergency setting is paramount for improving patient outcomes and healthcare costs. Monocyte anisocytosis, quantified as monocyte distribution width (MDW), has been shown to correspond with immune dysregulation. We hypothesize that MDW is broadly associated with illness severity related to sepsis and serious infection in children.
View Article and Find Full Text PDFMechanical Circulatory support for Septic Shock in Children and Adults: Different but Similar!
Can J Cardiol
December 2024
Senior Consultant Intensive Care, Royal Childrens Hospital, Melbourne, Australia; Professor Department of Critical Care, Faculty of Medicine, Melbourne University.
Whilst Extra-Corporeal Membrane Oxygenation (ECMO) for circulatory support in patients with severe septic shock, commenced in newborn infants and children in the late 1980's, ECMO has remained a controversial treatment for adults with refractory septic shock (RSS). This is fundamentally due to differences in the predominant hemodynamic response to sepsis. In newborn infants and very young children ventricular failure called Low Cardiac Output Syndrome (LCOS) is the major hemodynamic response whilst adolescents and adults have mainly vasoplegic shock.
View Article and Find Full Text PDF[Healthcare-Associated Infections in Pediatric Patients: A Decade of Experience in an Intensive Care Unit].
Acta Med Port
January 2025
Introduction: Healthcare-associated infections are an important cause of morbidity and mortality in the pediatric population and a growing problem in intensive care services. However, limited data are available on these infections in the Portuguese pediatric population. This study aimed to estimate its prevalence rate in a Portuguese pediatric intensive care unit, identifying the most frequent microorganisms and their antibiotic resistance profiles.
View Article and Find Full Text PDFNeonatal sepsis in Vietnam: Bacterial profiles and antibiotic susceptibility in a tertiary care setting.
Am J Infect Control
December 2024
Department of Microbiology, Vietnam National Children's Hospital, Hanoi, Vietnam.
Background: Neonatal sepsis is a leading cause of newborn mortality, particularly in low and middle-income countries. This study examines the bacterial etiologies and antibiotic resistance patterns of neonatal sepsis in a tertiary hospital in Vietnam.
Methods: A prospective cross-sectional study was conducted at National Children's Hospital, Hanoi, Vietnam from January 2021 to December 2022.
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