A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713763 | PMC |
| http://dx.doi.org/10.1021/cc700202c | DOI Listing |
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