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Golgi cell dendrites are restricted by Purkinje cell stripe boundaries in the adult mouse cerebellar cortex. | LitMetric

Golgi cell dendrites are restricted by Purkinje cell stripe boundaries in the adult mouse cerebellar cortex.

J Neurosci

Department of Cell Biology and Anatomy, Genes and Development Research Group, and Hotchkiss Brain Institute, Faculty of Medicine, The University of Calgary, Calgary, Alberta, Canada.

Published: March 2008

AI Article Synopsis

  • - The study investigates the organization of cerebellar Golgi cell dendrites in relation to the distinct parasagittal stripes of Purkinje cells in the cerebellar cortex, which have unique molecular characteristics and connectivity features.
  • - Researchers employed three methods: immunofluorescence staining to visualize dendrites in context with Purkinje cell stripes, immunohistochemistry combined with a Golgi-Cox staining technique, and using a transgenic mouse model to highlight Golgi cell dendritic expression.
  • - Findings indicate that Golgi cell dendrites align with the delineated boundaries of the cerebellar stripe architecture, suggesting that the structure of these interneurons maintains the organization established by the surrounding Purkinje cell stripes.

Article Abstract

Despite the general uniformity in cellular composition of the adult cerebellar cortex, there is a complex underlying pattern of parasagittal stripes of Purkinje cells with characteristic molecular phenotypes and patterns of connectivity. It is not known whether interneuron processes are restricted at stripe boundaries. To begin to address the issue, three strategies were used to explore how cerebellar Golgi cell dendrites are organized with respect to parasagittal stripes: first, double immunofluorescence staining combining anti-neurogranin to identify Golgi cell dendrites with the Purkinje cell compartmentation antigens zebrin II/aldolase C, HNK-1, and phospholipase Cbeta4; second, zebrin II immunohistochemistry combined with a rapid Golgi-Cox impregnation procedure to reveal Golgi cell dendritic arbors; third, stripe antigen expression was used on sections of a GlyT2-EGFP transgenic mouse in which reporter expression is prominent in Golgi cell dendrites. In each case, the dendritic projections of Golgi cells were studied in the vicinity of Purkinje cell stripe boundaries. The data presented here show that the dendrites of a cerebellar interneuron, the Golgi cell, respect the fundamental cerebellar stripe cytoarchitecture.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670690PMC
http://dx.doi.org/10.1523/JNEUROSCI.4145-07.2008DOI Listing

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