To evaluate the diagnostic and prognostic value of PIC, we compared it with the DIC score (which is calculated from platelet count, fibrinogen, FDP, and prothrombin time). We examined 182 samples from 60 patients with coaglo-fibrinolytic abnormalities. For the diagnosis of DIC, the sensitivity of PIC was significantly higher than that of DIC score (78.46% vs 43.08%; chi 2-test p less than 0.01), although the specificity of PIC was significantly lower than that of DIC score (32.48% vs 69.23%; chi 2-test p less than 0.01). For the prediction of prognosis, the peak value of PIC and DIC score during the patient's clinical course were evaluated. The non-survivors (n = 33) had significantly higher levels of peak PIC and DIC scores than the survivors (n = 27) (peak PIC: 6.1 + 9.0 micrograms/ml vs 2.2 + 3.3, p less than 0.05; peak DIC score: 4.6 + 2.4 points vs 3.3 + 2.2, p less than 0.05). The patients with a peak PIC of more than 4.0 micrograms/ml had a mortality of over 90%. These results show that PIC is a useful diagnostic and prognostic parameter.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A nomogram based on InLDH and InNLR for predicting disseminated intravascular coagulation in patients with heat stroke.
Ther Adv Hematol
January 2025
Department of Intensive Care Unit, General Hospital of Southern Theatre Command of PLA, #111 Liuhua Road, Guangzhou, 510010, Guangdong, China.
Background: Heat stroke (HS), a potentially fatal heat-related illness, is often accompanied by disseminated intravascular coagulation (DIC) early, resulting in a poorer prognosis. Unfortunately, diagnosis by current DIC scores is often too late to identify DIC. This study aims to investigate the predictors and predictive model of DIC in HS to identify DIC early.
View Article and Find Full Text PDFDisseminated Intravascular Coagulation in Pediatric Acute Leukemia: Prevalence, Laboratory Features, and Prognostic Significance of ISTH Score.
Int J Lab Hematol
January 2025
Department of Hematology and Coagulation, Princess Iman Center for Research and Laboratory Sciences, Amman, Jordan.
Introduction: Disseminated intravascular coagulation (DIC) is associated with acute leukemia. DIC prevalence and clinical consequences are complex and varies across acute leukemia subtypes. The International Society of Thrombosis and Hemostasis (ISTH) scoring system is used for the detection of overt DIC.
View Article and Find Full Text PDFAge at Menarche and Coronary Artery Disease Risk: Divergent Associations with Different Sources of Variation.
medRxiv
December 2024
Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital.
Background: In women, both earlier and later age at menarche (AAM) are associated with increased risk of coronary artery disease (CAD). This study sought to determine if the relationship of AAM with CAD and CAD risk factors differs for different underlying sources of variation in AAM - specifically, variation attributable to common genetic variants as represented by a polygenic score (PGS) vs. variation in AAM adjusted for the PGS.
View Article and Find Full Text PDFDisseminated intravascular coagulation is associated with a poor outcome in patients with out-of-hospital cardiac arrest receiving VA-ECMO.
J Artif Organs
January 2025
Department of Anesthesiology and Critical Care Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan.
Article Synopsis
- The study tested if disseminated intravascular coagulation (DIC) is linked to worse outcomes in patients who had out-of-hospital cardiac arrest (OHCA) and received veno-arterial extracorporeal membrane oxygenation (VA-ECMO) treatment.
- 57 patients were divided into two groups: those with DIC (30 patients) and those without (27 patients) and mortality rates were compared.
- Results showed that patients with DIC had significantly higher in-hospital mortality, and DIC scores measured after 24 hours proved to be a moderate predictor of death in these patients.
Analysis of Modified ISTH DIC Score in Cases of Abruptio Placentae and Its Correlation with Severity of Abruptio Placentae.
J Obstet Gynaecol India
December 2024
Department of Obstetrics & Gynecology, N.S.C.B Medical College, Jabalpur, M.P. India.
Background: Disseminated intravascular coagulation (DIC) is a potentially fatal condition which is always secondary to an underlying disorder with abruption being the most common cause in obstetrics.Our study analysed the modified International Society of Thrombosis and Haemostasis DIC score for prediction of DIC in cases of abruptio placentae. Additionally, we correlated the score with severity of abruption to optimize its use in limited resource settings.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!