Little is known about how frail, elderly women in assisted living and long-term care facilities view pelvic floor dysfunctions and treatments. Twenty-five residents reflect on these issues, and quality of life.
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Alzheimers Dement
December 2024
INCT - NeuroTecR and CTMM, Belo Horizonte, Minas Gerais, Brazil.
Background: Post-Covid syndrome has been associated to enduring impairments in functionality, cognition, mood and physical capabilities among older adults.
Methods: The objective was to prospectively evaluate clinical, cognitive and functional impairments in elderly people at 3 and 12 months after the diagnosis of Covid-19. Prospective cohort study of participants aged 60 years and over after a Covid-19 diagnosis.
Alzheimers Dement
December 2024
Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore, Singapore.
Background: Intrinsic capacity (IC) and frailty are inter-related yet distinct constructs which encapsulate functional capacities of older adults. There is uncertainty how IC is related to and interacts with the social (SF) and physical (PF) dimensions of frailty to influence cognition. We aim to examine IC, PF and SF profiles and compare the association between identified subtypes with change in cognition at 2 years METHODS: We studied 230 healthy community-dwelling older adults (age:67.
View Article and Find Full Text PDFFundam Clin Pharmacol
February 2025
PRISM Biogénopôle La Timone University Hospital of Marseille, APHM, Marseille, France.
Background: Imatinib is the treatment of elderly or frail patients with chronic myeloid leukemia (CML). Trough levels of around 1000 ng/ml are considered as the target exposure.
Objectives: We searched for baseline parameters associated with imatinib pharmacokinetics, and studied the clinical impact of subsequent adaptive dosing.
Clin Interv Aging
January 2025
Department of Emergency, The People's Hospital of Baoan Shenzhen, Shenzhen, Guangdong, People's Republic of China.
Background: The interplay between cognitive frailty and depression remains inadequately understood, with a paucity of evidence from prospective cohort studies. Our study aims to elucidate the relationship between cognitive frailty and the risk of incident depression.
Methods: Utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) spanning 2011, 2013, and 2015, subjects were classified according to cognitive frailty criteria established by an international consensus panel.
BJU Int
January 2025
Department of Urology, Singapore General Hospital, Singapore, Singapore.
Compelling evidence has solidified the notion of early treatment intensification in managing patients with metastatic hormone-sensitive prostate cancer (mHSPC). Landmark trials have provided Level 1 evidence for the survival benefits achieved by combining multiple agents. The efficacy of combined therapy relies not only on how treatment is intensified but also on how it is de-escalated.
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