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Risk factors for Staphylococcus aureus colonization in a general emergency department patient cohort - results of an observational cohort study.
Biomarkers
January 2025
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Division of Emergency Medicine, Campus Virchow-Klinikum and Campus Charité Mitte, Berlin, Germany.
Background: Testing for (SA) colonization in emergency department (ED) patients may guide prevention strategies against hospital acquired infections (HAI). This study determined the prevalence of SA carriers in a general ED population, characterized the population, and identified predictors for SA colonization.
Methods: A prospective monocentric observational cohort study in a tertiary care hospital collected nasopharyngeal swabs in 1,000 adult patients.
Assessment of biofilm formation, antibiotic resistance patterns, and the prevalence of adhesion-related genes in clinical isolates.
Heliyon
January 2025
Department of Basic Medical Sciences, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran.
Background: This study aimed to evaluate the biofilm formation abilities of clinical strains, assess their antibiotic susceptibility patterns, and identify the prevalence of adhesion-associated genes.
Methodology: In this study, a total of 60 strains were collected from urine, pus, wounds, blood, body fluid, and sputum in health centers affiliated with Abadan University of Medical Sciences, Iran. Strains were identified via microbiological methods and polymerase chain reaction (PCR) to target the gene.
Umbrella review of economic evaluations of interventions for the prevention and management of healthcare-associated infections in adult hospital patients.
J Hosp Infect
January 2025
HCAI/AMR Modelling and Evaluations Team, UK Health Security Agency, London, UK.
Introduction: Healthcare-associated infections result in worse outcomes for patients and greater financial burden. An estimated 4.8 million HCAIs occurred in hospitals across Europe in 2022-23.
View Article and Find Full Text PDFDual Viral Infections and Para-Pneumonic Effusion in a Pediatric Patient: A Case of Respiratory Syncytial Virus and COVID-19 Complication.
Cureus
December 2024
Pediatric Intensive Care Unit, Pediatric Department, King Saud University Medical City, College of Medicine, King Saud University, Riyadh, SAU.
Para-pneumonic effusion in children is often associated with bacterial infections; however, dual viral infections, including respiratory syncytial virus (RSV) and COVID-19, can also lead to severe respiratory complications, as demonstrated in this case. This case report presents the clinical course of a pediatric patient with both RSV and COVID-19 infections, leading to para-pneumonic effusion. A three-year-old girl with a history of asthma and prior febrile convulsions presented to the Emergency Department with fever, cough, vomiting, and fatigue.
View Article and Find Full Text PDFEnhanced antibacterial and antibiofilm activities of quaternized ultra-highly deacetylated chitosan against multidrug-resistant bacteria.
Int J Biol Macromol
January 2025
Institute of Hepatobiliary Diseases, Transplant Center, Zhongnan Hospital, Hubei Engineering Center of Natural Polymers-based Medical Materials, Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. Electronic address:
Multidrug-resistant (MDR) bacterial infections pose a severe threat to global public health and present significant challenges in the treatment of bacterial keratitis. The escalation of antimicrobial resistance (AMR) underscores the urgent need for alternative therapeutic strategies. In this study, we report the homogeneous synthesis of quaternized ultra-highly deacetylated chitosan (QUDCS) using a sequential acid-base combination approach.
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