AI Article Synopsis
- The study compares metabolic syndrome and coronary heart disease (CHD) risk in adults with chronic spinal cord injury (SCI) to the general North American population.
- Results show that metabolic syndrome prevalence is significantly lower in SCI individuals, with only 3.1% classified as high risk for CHD using the Framingham risk scoring method.
- The study suggests that current assessment tools may not accurately reflect true CHD risk in those with SCI, highlighting the need for more precise screening methods that incorporate factors like high-sensitivity C-reactive protein (CRP).
Article Abstract
Study Design: Cross-sectional, observational study.
Objectives: To quantify, in adults with chronic spinal cord injury (SCI): (1) presence of metabolic syndrome versus the general North American population (GP) and (2) 10-year coronary heart disease (CHD) risk using Framingham risk scoring (FRS).
Setting: Ontario, Canada.
Methods: Fasting anthropometric and biochemical data were collected from 75 adults with chronic SCI. Metabolic syndrome was determined using four internationally recognized definitions and FRS using the most recent (2001) algorithm.
Results: Prevalence of metabolic syndrome was up to 5.4 times lower in SCI participants compared to GP, and FRS categorized 3.1% of participants as being at high 10-year CHD risk. However, high-sensitivity C-reactive protein (CRP) values indicated 36.7% of participants as being at high CHD risk.
Conclusion: Current metabolic syndrome definitions and FRS may underestimate true CHD risk in people with SCI. Tools that better identify CHD risk require validation in the SCI population. CRP may be a potential factor to consider in the development of SCI-specific screening tools.
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| http://dx.doi.org/10.1038/sc.2008.21 | DOI Listing |
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