The design and synthesis of 16-membered macrolides modified at the C-3 position are described. Starting from fully protected intermediate (5), appropriate modifications including Heck reaction were performed to furnish 3-O-(3-aryl-2-propenyl)leucomycin A(7) analogues (9a-9m). These leucomycin A(7) derivatives showed improved in vitro antibacterial activities against clinically important pathogens including erythromycin-resistant Streptococcus pneumoniae (ERSP). SAR analysis of derivatives modified at the C-3 and C-3'' positions suggested that single modification at C-3 or C-3'' was effective for in vitro antibacterial activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2008.02.064 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
g-CN Modified with Metal Sulfides for Visible-Light-Driven Photocatalytic Degradation of Organic Pollutants.
Molecules
January 2025
Research Group of Environmental and Inorganic Photochemistry, Center for Natural Sciences, Faculty of Engineering, University of Pannonia, P.O. Box 158, H-8201 Veszprém, Hungary.
Graphitic carbon nitride (g-CN) proved to be a promising semiconductor for the photocatalytic degradation of various organic pollutants. However, its efficacy is limited by a fast electron hole recombination, a restricted quantity of active sites, and a modest absorption in the visible range. To overcome these limitations, g-CN-BiS and g-CN-ZnS composites were effectively produced utilizing a starch-assisted technique.
View Article and Find Full Text PDFPrint-Light-Synthesis of ruthenium oxide thin film electrodes for electrochemical sensing applications.
Bioelectrochemistry
January 2025
University of Bologna, Department of Industrial Chemistry "Toso Montanari", Center of Chemical Catalysis-C(3), Via Piero Gobetti 85, 40129 Bologna, Italy. Electronic address:
Print-Light-Synthesis (PLS) combines the inkjet printing of a ruthenium precursor ink with the simultaneous photo-induced generation of ruthenium oxide films. During PLS, inkjet-printing generates on conductive as well as insulating substrates micrometer-thin reaction volumes that contain with high precision defined precursor loadings. Upon direct UV light irradiation, the Ru precursor converts to RuO while all other ink components escape in the gas phase.
View Article and Find Full Text PDFUnveiling the role of NiFeM hydroxide (M = Pt, Ru, Ir, Rh) cocatalysts for robust H production in photocatalytic water splitting.
Chem Commun (Camb)
January 2025
Fujian Provincial Key Laboratory of Polymer Materials, College of Materials Science and Engineering, Fujian Normal University, Fuzhou 350007, China.
In this study, the NiFe-LDH doped with different Pt group metals (Pt, Ru, Ir, Rh) was prepared as a cocatalyst for photocatalytic H production over g-CN. It is found that the doped NiFe-LDH loaded g-CN generally displays higher photocatalytic activity than the raw NiFe-LDH modified one, where the NiFeRu-LDH loaded g-CN shows the optimal H evolution rate of 77.4 μmol h, about 5.
View Article and Find Full Text PDFLoading with non-metal cocatalysts to regulate interfacial charge transfer and separation has become a prominent focus in current research. In this study, g-CN/CNT composites loaded with non-metallic cocatalysts were prepared through pyrolysis using urea and CNTs. Various characterization techniques, including transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS), photoelectrochemical (PEC) analysis, fluorescence lifetime spectroscopy (TRPL), electron paramagnetic resonance spectroscopy (ESR), and photoluminescence (PL) spectroscopy, were employed to analyze the sample's microstructure, phase composition, elemental chemical states, and photoelectronic properties.
View Article and Find Full Text PDFA carbon fiber modified with tin oxide/graphitic carbon nitride as an electrochemical indirect competitive immuno-sensor for ultrasensitive aflatoxin M detection.
Bioelectrochemistry
January 2025
Department of Chemistry, Govt. College Women University, Arfa Kareem Road, Faisalabad 38000 Pakistan. Electronic address:
The importance of developing multifunctional nanomaterials for sensing technologies is increasing with the arrival of nanotechnology. In this study, we describe the introduction of novel nanoprobe electro-active material into the architecture of an electrochemical immuno-sensor. Based on the electrochemical immuno-sensor, functionalized tin oxide/graphitic carbon nitride nanocomposite (fSnO/g-CN) was synthesized and then analyte specific anti-aflatoxin M monoclonal antibody (AFM-ab) combined to form an electro-active nanoprobe (fSnO/g-CN/AFM-ab).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!