AI Article Synopsis
- Artelastin, a flavone from Artocarpus elasticus, inhibits the production of reactive oxygen species (ROS) in human neutrophils through effective scavenging of superoxide anion (O2-).
- It does not affect myeloperoxidase (MPO) activity, indicating a specific action on ROS rather than a general effect on neutrophil function.
- Artelastin also reduces nitric oxide (NO) production in macrophages by interfering with the expression of inducible nitric oxide synthase (iNOS) following stimulation, without scavenging NO directly.
Article Abstract
Artelastin, a prenylated flavone previously isolated from Artocarpus elasticus, was evaluated for its effect on the production of reactive oxygen species (ROS) by human polymorphonuclear neutrophils (PMNs) and nitric oxide (NO) by J774 murine macrophage cell line. Artelastin showed to be an inhibitor of ROS production due to a strong O2- scavenging activity. No effect was observed on the activity of myeloperoxidase (MPO). Artelastin showed also to be an inhibitor of NO production without NO scavenging activity. This flavone seems to interfere with the expression of the inducible nitric oxide synthase (iNOS) immediately after LPS-IFNgamma-macrophage stimulation.
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| http://dx.doi.org/10.1016/j.intimp.2007.12.013 | DOI Listing |
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