Objective: To explore the effect of aminoguanidine (AG) on hemodynamics and nitric oxide (NO) in hemorrhagic shock in rabbit.
Methods: Shock was produced in twenty rabbits by femoral artery blood letting, and they were randomly divided into two groups with treatment with saline (control group) or AG (each n=10). Pclab system and nitric acid reductase methods were performed to detect hemodynamics parameters and NO levels at preshock, postshock (30 minutes and 150 minutes) and 30 minutes and 180 minutes after resuscitation respectively.
Results: No significant differences were observed in hemodynamics parameters and NO levels between the two groups before resuscitation. Whereas after resuscitation, hemodynamics parameters such as systolic arterial pressure (SAP), heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP) and the max and minimum first derivative of left ventricular pressure (+/-dp/dt max) were all improved greatly in the two groups. AG decreased serum NO level significantly, while saline did not have such effect, suggesting that AG had a longer and more efficient effect against hemorrhagic shock (P<0.05 or P<0.01).
Conclusion: AG can improve hemodynamics parameters and decrease NO level in hemorrhagic shock in rabbit.
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