The palladium-catalyzed carboannulation and arylation reaction of propargylic carbonates with in situ generated organozinc compounds produced an important new class of indene derivatives. The reaction proceeded under mild conditions, and indene products were isolated in good to excellent yields.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/b719957k | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Selective Synthesis of Tetrahydroisoquinoline and Piperidine Scaffolds by Oxidative Ring Opening/Ring Closing Protocols of Substituted Indenes and Cyclopentenes.
ChemistryOpen
December 2024
MTA TTK Lendület Artificial Transporter Research Group, Institute of Materials and Environmental Chemistry, HUN-REN Research Center for Natural Sciences, H-1117, Budapest, Magyar tudósok krt. 2, Hungary.
Novel tetrahydroisoquinoline and piperidine derivatives were selectively synthesized from substituted indenes or cyclopentenes. The process starts with an oxidative cleavage of the ring olefin bond, which gives reactive diformyl intermediates. By a ring-closing step using chiral (R) or (S) α-methylbenzylamine under a reductive amination protocol facilitated ring formation with ring expansion of the corresponding nitrogen-containing heterocycles.
View Article and Find Full Text PDFNovel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8CD69CD103 T cells.
J Transl Med
December 2024
Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Background: Renal CD8 tissue-resident memory T (T) cells display prolonged survival and activity in lupus nephritis (LN), exacerbating renal pathology. NLRP3 regulates the T cell response. This study explored the impact of NLRP3 inflammasome activity on the regulatory functions of T cells in LN.
View Article and Find Full Text PDFPlatinum-Acetylide Complexes as Nonfullerene Acceptors in Organic Photovoltaic Systems.
Inorg Chem
December 2024
Department of Energy and Materials, Kindai University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502 Japan.
Three distinct n-type semiconductors were derived from a platinum-trialkyl phosphine complex; to lower their LUMO levels, various indene derivatives were incorporated using thiophene (PtTIC ()), thieno[3,2-]thiophene (PtT2IC ()), and 4-cyclopenta[2,1-:3,4-']dithiophene (PtCDTIC ()) as the acetylide donor units. Single-crystal X-ray diffractometry analysis revealed translinear platinum-acetylide complexation in all cases. The strong (═O···S) interactions between the oxygen atoms of the indene acceptor units and the sulfur atoms of the thiophene-derived donor units induced a highly planar orientation among the heterocyclic ligands, featuring π-π interactions between the planes.
View Article and Find Full Text PDFDistribution, frequency and molecular basis of penoxsulam, metamifop and florpyrauxifen-benzyl resistance in Echinocloa spp. from rice fields across Jiangsu Province, China.
Pestic Biochem Physiol
January 2025
College of Plant Protection, Yangzhou University, Yangzhou, China. Electronic address:
Barnyard grasses (Echinochloa spp.) are the most troublesome weeds in rice ecosystems of Jiangsu Province, China, and long-term use of herbicides inevitably cause the development of resistance. In this study, 122 field-sampled populations were tested for resistance to penoxsulam (PEN), metamifop (MET), florpyrauxifen-benzyl, (FPB), propanil, and tripyrasulfone.
View Article and Find Full Text PDFExploring the potential of plasma and adipose mesenchymal stem cell-derived extracellular vesicles as novel platforms for neuroinflammation therapy.
J Control Release
January 2025
INRS, Centre Armand-Frappier Santé Biotechnologie, 531 Boul des Prairies, Laval, QC H7V 1B7, Canada. Electronic address:
Persistent reactive oxygen species (ROS) and neuroinflammation contribute to the onset and progression of neurodegenerative diseases, underscoring the need for targeted therapeutic strategies to mitigate these effects. Extracellular vesicles (EVs) show promise in drug delivery due to their biocompatibility, ability to cross biological barriers, and specific interactions with cell and tissue receptors. In this study, we demonstrated that human plasma-derived EVs (pEVs) exhibit higher brain-targeting specificity, while adipose-derived mesenchymal stem cells EVs (ADMSC-EVs) offer regenerative and immunomodulatory properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!