Broadening inclusion of vulnerable populations in HIV vaccine trials.

Expert Rev Vaccines

Vaccine Clinical Research Branch, Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, NIH, 6700 B Rockledge Drive, Room 5126, Bethesda, MD 20817, USA.

Published: March 2008

AI Article Synopsis

  • The development of a preventive HIV vaccine is urgently needed, particularly for at-risk groups like infants of HIV-infected women, adolescents, and injection drug users.
  • A comprehensive strategy is essential for creating a safe and effective vaccine that can be licensed for these populations along with sexually active adults.
  • Recent setbacks, such as the early termination of a Phase IIb trial, highlight the scientific, operational, and ethical challenges faced in advancing HIV vaccines for these vulnerable groups.

Article Abstract

The urgent need for a preventive HIV vaccine, as well as the complexities of its development, calls for timely and reinforced efforts to ensure vaccine licensure for use in a broad range of at-risk populations from the outset. Such an integrated strategy to HIV vaccine development should include infants of HIV-infected women, adolescents and injection drug users. A safe and effective HIV vaccine licensed for use in these populations, in addition to sexually active adults, would probably have the most timely and profound impact on the HIV/AIDS pandemic. Advanced clinical development of HIV vaccines in these vulnerable populations imposes particular scientific, operational and ethical challenges. Recent developments, including the early termination of a Phase IIb trial, present additional previously unanticipated challenges.

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Source
http://dx.doi.org/10.1586/14760584.7.2.259DOI Listing

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