AI Article Synopsis
- The izumi shrimp, an underutilized seafood resource from Tokushima Prefecture, has shown potential health benefits in previous research related to blood pressure.
- Two specific peptides were isolated from an izumi shrimp hydrolysate, which were found to significantly reduce blood pressure in hypertensive rats when administered orally.
- The study also indicated that the shrimp hydrolysate has low antigenicity and allergenicity, suggesting it is safe for consumption.
Article Abstract
The izumi shrimp (Plesionika izumiae Omori, 1971) is an unused resource which can be caught off the southern coast of Tokushima Prefecture. We have previously found that an izumi shrimp hydrolysate significantly inhibited the age-associated spontaneous increase in blood pressure in stroke-prone spontaneously hypertensive rats. In this present study, two angiotensin I-converting enzyme inhibitory peptides were isolated from an izumi shrimp hydrolysate by using high-performance liquid chromatography, and their amino acid sequences were determined to be Val-Trp-Tyr-His-Thr and Val-Trp. A single oral administration of synthetic Val-Trp-Tyr-His-Thr or Val-Trp significantly decreased the blood pressure in stroke-prone spontaneously hypertensive rats. The antigenicity and allergenicity of the izumi shrimp hydrolysate against BALB/c mice were very low. These results demonstrate that the angiotensin I-converting enzyme inhibitory peptides isolated from the izumi shrimp hydrolysate had an anti-hypertensive effect on rats.
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| http://dx.doi.org/10.1271/bbb.70565 | DOI Listing |
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