The microcapsules with entrapped herbal water-soluble extracts Plantago major and Calendula officinalis L. (HE) were prepared by LbL-adsorption of carrageenan and modificated chitosan onto CaCO3 microparticles with their subsequent dissolving after the treatment of EDTA. Entrapment of HE was performed by adsorption and co-precipitation techniques. The co-precipitation provided better entrapment of HE compared to adsorption. In vitro release kinetics in an artificial gastric juice (AGJ) was studied. The HE release was shown to accelerate gastric ulcer treatment in a rat model.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Innovative rheumatoid arthritis management using injection replacement approach via dual therapeutic effects of hyalurosomes-encapsulated luteolin and dexamethasone.
Colloids Surf B Biointerfaces
January 2025
Department of Pharmaceutics, Damanhour University, P.O. Box 22511, Damanhour, Egypt.
Rheumatoid arthritis is a highly prevalent debilitating condition linked to inflammation. The effectiveness of the present therapeutic techniques is constrained; so, there is an urgent requirement for a novel nanoplatform entailing drugs with proven efficacy. The current work highlighted the development of dexamethasone and luteolin co-encapsulated hyalurosomes (LUT-DEX hyalurosomes).
View Article and Find Full Text PDFPreparation, Characterization, and Evaluation of Chlorogenic Acid Loaded Hydrogel Beads for the Management of Ulcerative Colitis.
Assay Drug Dev Technol
January 2025
Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia.
SLNs and NLCs for Skin Applications: Enhancing the Bioavailability of Natural Bioactives.
Pharmaceutics
September 2024
Department of Dermopharmacy and Cosmetics, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 12 I. Creanga Street, 400010 Cluj-Napoca, Romania.
Natural bioactives are mixtures of compounds extracted from plants with physicochemical properties that are usually not favorable for penetrating the skin's complex barrier. Nanoparticles have important advantages both in dermatology and cosmetology: improved solubility and stability of encapsulated phytocompounds, controlled and sustained skin delivery, and enhanced skin permeation, leading to an improved bioavailability. This review focuses on two generations of lipid-based nanoparticles: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs).
View Article and Find Full Text PDFNucleic acid-based nanotherapeutics for treating sepsis and associated organ injuries.
Theranostics
August 2024
Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.
In recent years, gene therapy has been made possible with the success of nucleic acid drugs against sepsis and its related organ dysfunction. Therapeutics based on nucleic acids such as small interfering RNAs (siRNAs), microRNAs (miRNAs), messenger RNAs (mRNAs), and plasmid DNAs (pDNAs) guarantee to treat previously undruggable diseases. The advantage of nucleic acid-based therapy against sepsis lies in the development of nanocarriers, achieving targeted and controlled gene delivery for improved efficacy with minimal adverse effects.
View Article and Find Full Text PDFSynthesis and characterization of nano-biopolymer carriers loaded with clove ( L.) extract as an anticancer agent: an study.
J Biomater Sci Polym Ed
October 2024
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
The objective of this work was to design a new drug nanoparticle (NP) composed of chitosan/β-cyclodextrin/sodium tripolyphosphate/alginate (CS/βCD/TPP/AL) loaded with a clove extract (CE) for potential anticancer effects. The extract was prepared by two extraction methods: hydroalcoholic maceration (MAC) with 80% MeOH and supercritical fluid (SCF). The MACCE and SCFCE CE NPs had particle sizes of 71 nm and 20 nm, respectively with irregular spherical shapes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!