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Déjà-vu sensation induced by cortical stimulation of the posterior cingulate cortex.
Neurocase
December 2024
Division of Pediatric Neurology, Department of Neurology, University of Louisville, Louisville, KY, USA.
We report a case of a 19-year-old woman with drug-resistant focal epilepsy whose typical seizure semiology involved sensations of déjà-vu. She underwent intracranial stimulation, leading to déjà-vu upon stimulation of the posterior cingulate cortex (PCC). Most reports of induced déjà-vu and epilepsy-associated déjà-vu emphasize networks including temporal lobe, especially the rhinal cortices, as the generator of this phenomenon.
View Article and Find Full Text PDFDuties, tasks, knowledge and skills of an obesity medicine physician: A practice analysis.
Obes Pillars
December 2024
American Board of Obesity Medicine, Denver, CO, USA.
Background: Given the evolving nature of obesity medicine, periodic evaluation of its clinical practice is needed to ensure that certification requirements address real-world experience. Practice analysis is a systematic approach to define a field's body of knowledge, and its results can inform the content outline and examination blueprint for a certification examination. This study describes the 2023 practice analysis conducted by the American Board of Obesity Medicine (ABOM).
View Article and Find Full Text PDFAntiseizure medication-induced hypersensitivity reactions: Data from a large healthcare system.
Seizure
November 2024
Division of Child Neurology, Department of Pediatrics, University of Louisville School of Medicine, KY, 40202, USA; Norton Children's Neuroscience Institute and Children's Hospital, Louisville, KY 40202, USA.
Background And Objectives: Data on hypersensitivity reactions (HR) to individual anti-seizure medications (ASMs), and reactions to additional ASMs, is often limited by sample size. This data is vital in helping clinicians identify initial and subsequent ASMs to use in treating persons with epilepsy (PWE). Using a very large dataset, our study attempts to quantify the occurrence of HR across 31 different ASMs.
View Article and Find Full Text PDFPhysiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation.
Nat Commun
April 2024
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, 95064, USA.
Lactation insufficiency affects many women worldwide. During lactation, a large portion of mammary gland alveolar cells become polyploid, but how these cells balance the hyperproliferation occurring during normal alveologenesis with terminal differentiation required for lactation is unknown. Here, we show that DNA damage accumulates due to replication stress during pregnancy, activating the DNA damage response.
View Article and Find Full Text PDFAge-associated sleep spindle characteristics in Duchenne muscular dystrophy.
Sleep Adv
March 2024
Center for Biobehavioral Health, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.
Brain oscillations of non-rapid eye movement sleep, including slow oscillations (SO, 0.5-1.5 Hz) and spindles (10-16 Hz), mirror underlying brain maturation across development and are associated with cognition.
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