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Severe allergic rash induced by icodextrin: case report and literature review.
Front Med (Lausanne)
October 2024
Department of Nephrology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China.
Background: Icodextrin is a type of peritoneal dialysis (PD) osmolyte that can be extended retention times (8-16 h) and may offer a viable alternative to conventional glucose dialysis solutions for PD patients. Nonetheless, prolonged use of icodextrin may lead to allergic rash, and rarely severe skin lesions.
Case Presentation: In February 2024, a 45-year-old male was admitted to the Department of Nephrology at Shaoxing Second Hospital presenting with a 3-day history of intense generalized pruritic erythematous rash.
Helper T cell subsets: Development, function and clinical role in hypersensitivity reactions in the modern perspective.
Heliyon
May 2024
Division of Rheumatology and Clinical Immunology, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region of China.
Helper T cells are traditionally classified into T helper 1 (T1) and T helper 2 (T2). The more recent discoveries of T helper 17 (T17), follicular helper T cells (T) and regulatory T cells (T) enhanced our understanding on the mechanisms of immune function and hypersensitivity reactions, which shaped the modern perspective on the function and role of these different subsets of helper T cells in hypersensitivity reactions. Each subset of helper T cells has characteristic roles in different types of hypersensitivity reactions, hence giving rise to the respective characteristic clinical manifestations.
View Article and Find Full Text PDFMultiple drug hypersensitivity syndrome manifesting as acute generalised exanthematous pustulosis: A rare case report.
Contact Dermatitis
April 2024
Department of Allergy and Clinical Immunology, Centro Hospitalar Universitário de São João, Porto, Portugal.
Acute localised exanthematous pustulosis (ALEP)-induced by ioversol.
Contact Dermatitis
February 2024
Department of Neurosurgery, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, China.
Cutaneous adverse drug reactions.
Therapie
April 2024
EpiDermE, université Paris Est Créteil Val-de-Marne, 94000 Créteil, France; Groupe FISARD de la Société française de dermatologie, France; Service de pharmacologie médicale, centre régional de pharmacovigilance Pitié-Saint-Antoine, groupe hospitalier AP-HP-Sorbonne université, 75013 Paris, France. Electronic address:
Cutaneous adverse drug reactions (ADRs) represent a heterogeneous field including various clinical patterns without specific features suggesting drug causality. Maculopapular exanthema and urticaria are the most common types of cutaneous ADR. Serious cutaneous ADRs, which may cause permanent sequelae or have fatal outcome, may represent 2% of all cutaneous ADR and must be quickly identified to guide their management.
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