Several studies have demonstrated a link between blood viscosity and various forms of liver dysfunction. Therefore, we investigated the effect of liver protective herbal materials, Sesamin combined with extract of Schisandra chinensis berry (Schisandra) for its potential to improve blood fluidity in humans. Ten human subjects were recruited to study the effect of sesamin combined with schisandra extract (SCH) for two weeks on blood viscosity. Blood fluidity was measured as the transit time for 100mul of heparinized whole blood to pass through a micro-channel array setup at baseline, 1 week and 2 weeks. For safety assessment, blood biochemistry, hematology and urine analysis were taken at baseline, 1 week and 2 weeks after SCH administration. No safety concern and adverse effects were observed during the 2-week continuous intake period. Intake of SCH reduced blood passage time by 9.0% and 9.7% at 1 and 2 weeks, respectively. In conclusion, this pilot clinical study indicates that the combined administration of sesamin with schisandra extract could improve blood fluidity after 1 week of oral intake and this effect was sustained up to 2 weeks.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258427 | PMC |
| http://dx.doi.org/10.6026/97320630002249 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut-Brain Axis.
Molecules
December 2024
Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159C, 02-776 Warsaw, Poland.
The gut-brain axis (GBA) is a complex communication network connecting the gastrointestinal tract (GIT) and the central nervous system (CNS) through neuronal, endocrine, metabolic, and immune pathways. Omega-3 (n-3) fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are crucial food components that may modulate the function of this axis through molecular mechanisms. Derived mainly from marine sources, these long-chain polyunsaturated fatty acids are integral to cell membrane structure, enhancing fluidity and influencing neurotransmitter function and signal transduction.
View Article and Find Full Text PDFRed blood cell changes due to cancer and cancer treatments: a narrative review.
Curr Opin Hematol
January 2025
Department of Biomedical and Molecular Sciences, Queen's University.
Purpose Of Review: To date, there is relatively limited research investigating changes in red blood cells (RBCs), particularly qualitative changes, in cancer patients and cancer patients receiving treatment. These changes may be important in better understanding cancer-associated anemia, which is the most prevalent hematological disorder in cancer patients with wide-ranging implications on patient care and quality of life. This review aims to summarize available evidence regarding qualitative and quantitative changes in RBCs in individuals with cancer prior to treatment and in patients undergoing treatment.
View Article and Find Full Text PDFErythrocyte Membrane Fluidity and Omega-3 Fatty Acid Intake: Current Outlook and Perspectives for a Novel, Nutritionally Modifiable Cardiovascular Risk Factor.
Nutrients
December 2024
Endocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00136 Rome, Italy.
Omega-3 fatty acids reduce triglycerides and have several positive effects on different organs and systems. They are also found in the plasma membrane in variable amounts in relation to genetics and diet. However, it is still unclear whether omega-3 supplementation can reduce the occurrence of major cardiovascular events (MACEs).
View Article and Find Full Text PDFEffects of Different Concentrations of AmB on the Unsaturated Phospholipid-Cholesterol Membrane Using the Langmuir Monolayer and Liposome Models.
Molecules
November 2024
Xi'an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device, School of Electronic Information, Xijing University, Xi'an 710123, China.
Article Synopsis
- Amphotericin B (AmB) causes toxicity to red blood cell membranes, leading to hemolysis and limiting its effective use in treating invasive fungal infections.
- The study investigated how different concentrations of AmB (5, 45, 85, and 125 μg/mL) interact with unsaturated phospholipid membranes containing cholesterol, using methods like the Langmuir model and fluorescence techniques.
- Findings revealed that as AmB concentration increases, it not only alters the organization and elasticity of the membrane but also affects the balance between hydrophobic and hydrophilic domains, particularly when concentrations exceed 85 μg/mL.
Microwave replacing traditional concentrating process to promote the synthesis of mumefural in Prunus mume extract.
Food Res Int
January 2025
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China; Sanya Institute of Nanjing Agricultural University, Sanya, Hainan 572024, China. Electronic address:
Mumefural (MF), the primary functional ingredient of prunus mume extract that enhances blood fluidity, is produced by boiling the prunus mume juice for 24-48 h in a traditional one-step concentration process. Low MF yields and long processing time are two disadvantages of this process. This study introduced microwaves into the traditional one-step concentration process of prunus mume extract for increasing MF content.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!