Antiretroviral therapy available in 2008 have shown their capacity to reduce the morbidity and mortality associated with infection by the human immunodeficiency virus (HIV) but do not eradicate the virus. Treatment of HIV infection is the subject of French and international guidelines, updated regularly as a function of available data on efficacy and toxicity as well as of the arrival of new drugs. The objective of antiretroviral therapy is to reduce viral replication as much as possible, making it undetectable in plasma, that is, to obtain a plasma viral load less than the detection threshold, generally < 50 copies/mL. Reasons that current therapy may not be effective include principally adhesion difficulties, toxicity, and the possibility of the emergence of resistant viruses. It is thus essential to continue developing new drugs and assessing new strategies for their use.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.lpm.2007.10.016 | DOI Listing |
Sci Rep
January 2025
Ph.D. Program in Global Health & Health Security, College of Public Health, Taipei Medical University, Taipei, Taiwan.
The COVID-19 pandemic may have impacted disabilities among people living with HIV; however, data on the association between COVID-19 pandemic-related healthcare disruptions and disabilities among people living with HIV is limited. We aimed to evaluate the association between COVID-19-affected HIV care behaviors and disability domains among people living with HIV in Belize. A cross-sectional study was conducted at the Western Regional Hospital and Southern Regional Hospital between August and October 2021 among people living with HIV in Belize aged ≥ 21 years and on antiretroviral therapy.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Statistics, College of Natural and Computational Science, Debre Tabor University, Debre Tabor, Ethiopia.
The human immunodeficiency virus systematically undermines the immune system, which serves as our body's inherent safeguard against diseases. Currently, it is the most serious threat to public health. Ethiopia is among the countries with the highest prevalence of HIV/AIDS.
View Article and Find Full Text PDFBMJ Glob Health
January 2025
School of Public Health, Makerere University, Kampala, Uganda.
Introduction: In Uganda, fisherfolk have an HIV prevalence between 15% and 40%, significantly higher than the national average of 5.5%. Pre-exposure prophylaxis (PrEP) is effective in preventing HIV but faces challenges in uptake and continuation among fisherfolk.
View Article and Find Full Text PDFClin Microbiol Infect
January 2025
Infectious Disease Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Electronic address:
Background: The World Health Organization (WHO) recommends antiretroviral therapy (ART) containing two nucleoside reverse transcriptase inhibitors (NRTIs) as backbone. WHO recommends tenofovir disoproxil fumarate combined with lamivudine or emtricitabine as first line in pregnancy, and zidovudine, abacavir or tenofovir alafenamide, combined with lamivudine or emtricitabine, as alternatives.
Objectives: Evaluate risk of adverse perinatal outcomes in pregnant women living with HIV (WLHIV) receiving different NRTIs.
J Acquir Immune Defic Syndr
January 2025
Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, US at the time this research was undertaken. Current affiliation: Manhattan Associates, Atlanta GA.
Background: In 2019, there were an estimated 1.2 million persons with HIV (PWH) and 35,100 new infections in the United States. The HIV care continuum has a large influence on transmission dynamics.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!