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Activity of Dimercaptosuccinic Acid in Combination with Carbapenems Against Carbapenem-Resistant .
Microb Drug Resist
November 2024
Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Carbapenenemase producers, particularly the metallo-β-lactamase (MBL) types in , have emerged as an urgent threat in health care settings. MBLs require zinc at their catalytic site and can be inhibited by dimercaptosuccinic acid (DMSA), a metal chelator known for the treatment of lead and mercury intoxication. Isogenic strains of wild-type and OprD-deleted PA14, were constructed, producing the MBLs VIM-2, NDM-1, SPM-1, IMP-1, and AIM-1, or the non-MBL carbapenemases, GES-5 and KPC-2.
View Article and Find Full Text PDFIntoxication in a Colombian mercury mine: Aranzazu, 1948-1975.
Hist Cienc Saude Manguinhos
October 2024
Titular Professor, Escuela de Historia/Universidad Industrial de Santander. Bucaramanga - Colombia
Article Synopsis
- - The study examines the experiences of "La Esperanza" mercury mine workers in Aranzazu, Colombia, from 1948 to 1975, focusing on their occupational hazards and health issues.
- - Workers faced severe health risks due to unstable geological conditions and poor mining technology, leading to symptoms like tremors, bleeding gums, and bad breath.
- - This situation initiated the field of occupational toxicology in Colombia, as the mine was the first to provide treatment for mercury poisoning using dimercaprol and penicillamine.
Intake rates of methylmercury in the Belgian population: Evolution over 40 years.
Sci Total Environ
December 2024
Archaeology, Environmental Changes and Geo-Chemistry (AMGC), Vrije Universiteit Brussel (VUB), Pleinlaan 2, 1050 Brussels, Belgium. Electronic address:
Article Synopsis
- * A study measured MeHg levels in various fish from North Sea catches, allowing researchers to calculate the daily mercury intake for the Belgian population in 1975, 1997, and 2014-2021, and compare these rates with international standards.
- * Although average MeHg intake rates in Belgium have decreased and are below the acceptable daily intake (ADI) norms, higher consumption levels (95th percentile rates) still pose risks, especially as MeHg levels in hair and blood indicate potential health effects in different age groups.
Environmental pollution challenges public health surveillance: the case of mercury exposure and intoxication in Brazil.
Lancet Reg Health Am
November 2024
Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém, Brazil.
Pollution, causing millions of deaths annually, disproportionally affects low- and middle-income countries (LMICs). Mercury ranks among the three main chemicals of major public health concern, and even low levels can cause cardiovascular and nervous outcomes, with children and indigenous populations being especially vulnerable. Nearly 80% of all emissions in South America originate from the Amazon.
View Article and Find Full Text PDF[Intoxications with trace metal elements: A new concept of the metal profile].
Ann Biol Clin (Paris)
August 2024
Laboratoire de Pharmacologie-Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohamed V de Rabat, 10001 Rabat, Maroc.
Article Synopsis
- * TMEs are categorized into essential elements (like iron and zinc) necessary for bodily functions and toxic elements (like mercury and lead) that are harmful and have no physiological role, with potential for illness stemming from both categories at high concentrations.
- * Techniques like Inductively Coupled Plasma Mass Spectrometry (ICP-MS) enhance detection and quantification of TMEs in biological samples, aiding in the diagnosis and management of TME intoxications through a novel approach known as the metal profile.
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