Safety and feasibility of transcatheter closure of large patent ductus arteriosus measuring >or=4 mm in patients weighing

Objectives: The study aims to find safety of transcatheter closure of large patent ductus arteriosus (PDA) >or=4 mm in patients weighing
Background: Large PDA >or=4 mm in patients
Methods: Preterm neonates and ducts with coarctation were excluded. All other patients were taken for catheter closure. Ducts with roomy ampulla were closed with multiple coils aided by bioptome, and others with Amplatzer duct occluders.

Results: Twenty-eight patients aged 2-18 months (median 5.5 months) and weighing 3.8-6 kg (median 4.7 kg) had large PDA (mean diameter 6.3 +/- 2 mm) with hyperkinetic pulmonary hypertension. Four patients had bioptome-aided coil closure. Twenty-two other ducts were closed with devices. Two procedures failed due to sheath kink in one patient and device pulling through a duct in the other patient. Four infants needed blood transfusions. The mean procedural time was 42 +/- 20 minutes. On a mean follow-up of 25.5 +/- 14.8 months, there were no residual flows and no gradients across aorta or pulmonary artery.

Conclusions: Transcatheter closure of large ducts >or=4 mm might be considered safe and effective in infants weighing