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Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats.
Cell Biochem Funct
December 2024
Department of Life and Consumer Sciences, University of South Florida, Roodepoort, South Africa.
Combination therapy offers a promising advantage because they target multiple pathways involved in the pathogenesis and progression of Alzheimer's disease. This study aimed to investigate the synergistic effect of donepezil and each of vitamin B12, vitamin B6 and vitamin B1 on aluminium chloride (AlCl)-induced neurotoxicity in rats. Fifty-four rats were divided into nine groups of six.
View Article and Find Full Text PDFPain-Induced Delirium in Patient with Dementia: A Case Report and Narrative Review.
J Pain Palliat Care Pharmacother
November 2024
Psychiatrist Consultant, Department of Psychiatry, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Pain management is the hallmark of palliative care; however, pain is commonly underassessed in cases of advanced dementia and delirium (acute confusional state). We present a case of a 66-year-old female patient with severe dementia who was hospitalized because of behavioral changes and sleep disturbance. Symptoms of confusion, disorientation, inattention, and agitation were most severe at night.
View Article and Find Full Text PDFPreparation and characterization of poly(ethylene glycol)--poly(-butyl methacrylate) micelles as potential nanocarriers for donepezil.
Pharm Dev Technol
December 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, Fatih, Istanbul, Turkey.
Polymeric micelles were prepared for the delivery of donepezil, a leading Alzheimer's disease drug, to enhance its transport across the blood-brain barrier (BBB). Poly(ethylene glycol)--poly(-butyl methacrylate) amphiphilic block copolymers were synthesized reversible addition-fragmentation chain transfer (RAFT) polymerization. The polymers were characterized by gel permeation chromatography and nuclear magnetic resonance spectroscopy.
View Article and Find Full Text PDFIn Vivo Evaluation of Nose-to-Brain Delivery of Liposomal Donepezil, Memantine, and BACE-1 siRNA for Alzheimer's Disease Therapy.
Int J Mol Sci
September 2024
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Our study took an innovative approach by evaluating, in vivo, the efficacy of intranasal (IN) administration of liposomal formulations of donepezil, memantine, and beta-site amyloid precursor protein-cleaving enzyme (BACE-1) siRNA, and their combination as a "triple-drug therapy" in treating Alzheimer's disease (AD). Female APP/PS1 homozygous, transgenic mice were used as an AD model. The spatial short-term memory of the APP/PS1 mice was evaluated by a Y-maze behavioral test.
View Article and Find Full Text PDFRepurposing of USFDA-approved drugs to identify leads for inhibition of acetylcholinesterase enzyme: a plausible utility as an anti-Alzheimer agent.
RSC Med Chem
September 2024
GITAM School of Pharmacy, GITAM (deemed to be) University Hyderabad India
In the quest to identify new anti-Alzheimer agents, we employed drug repositioning or drug repositioning techniques on approved USFDA small molecules. Herein, we report the structure-based virtual screening (SBVS) of 1880 USFDA-approved drugs. The -based identification was followed by calculating Prime MMGB-SA binding energy and molecular dynamics simulation studies.
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