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Fipronil in sub-lethal doses leads to immuno-toxicological effects in broiler birds.
PLoS One
January 2025
Department of Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
Pesticides, including fipronil, are used mainly in agriculture; however, in veterinary and animal husbandry, their potential use is to control the pests responsible for vector-borne diseases. Their residues in agriculture products and direct use on farms are responsible for potentially harming livestock and poultry. So, this study was designed to evaluate the toxico-pathological effects of fipronil on the immune system of poultry birds.
View Article and Find Full Text PDFGenomic interrogation of commercial infant probiotic products for label accuracy.
Pediatr Res
January 2025
Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Objective: To evaluate the label accuracy of commercial infant probiotic products and identify potential microbial contamination.
Methods: DNA was extracted from seventeen infant probiotic products purchased from a large online vendor. Samples underwent 16S ribosomal RNA gene sequencing, QIIME analysis, and bacterial taxonomic classification.
Detection of Insertion/Deletions (InDel) Within Five Clock Genes and Their Associations with Growth Traits in Four Chinese Sheep Breeds.
Vet Sci
January 2025
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Organisms have the capacity to detect day-night fluctuations through oscillators regulated by circadian clock genes, which are crucial for regulating various biological processes. Numerous studies have demonstrated a marked association between these genes and various growth traits of sheep. This study identified polymorphisms at 23 potential loci within five clock genes in four Chinese sheep breeds.
View Article and Find Full Text PDFRedefining supplier selection in healthcare sector: a novel framework for supplier classification.
J Health Organ Manag
January 2025
Amrita School of Business - Amritapuri Kollam Campus, Kollam, India.
Purpose: This paper aims to delve into the critical aspect of supplier selection in the healthcare sector, emphasizing the significance of strategic sourcing in enhancing operational efficiency and quality of services. The primary aim is to develop a comprehensive framework for supplier evaluation that aligns with the unique requirements of hospitals, ultimately improving procurement processes and patient care outcomes.
Design/methodology/approach: The study leverages the renowned Carter's 7 C model as a foundational framework for supplier assessment, supplemented by insights gathered from interviews with experts in the New Product Introduction, Purchasing and Procurement departments of a leading hospital in India.
Co-delivery of IL-1Ra and SOX9 via AAV inhibits inflammation and promotes cartilage repair in surgically induced osteoarthritis animal models.
Gene Ther
January 2025
School of Pharmacy, East China University of Science and Technology, Shanghai, China.
Osteoarthritis (OA), a prevalent joint disorder, can lead to disability, with no effective treatment available. Interleukin-1 (IL-1) plays a crucial role in the progression of OA, and its receptor antagonist (IL-1Ra), a natural IL-1 inhibitor, represents a promising therapeutic target by obstructing the IL-1 signaling pathway. This study delivered IL-1Ra via adeno-associated virus (AAV), a gene therapy vector enabling long-term protein expression, to treat knee osteoarthritis (KOA) in animal models.
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