AI Article Synopsis
- Different species respond to CO2 with varying olfactory behaviors, where Drosophila exhibits avoidance through antenna-based neurons, while mosquitoes display attraction via maxillary palps.
- In Drosophila, loss of the microRNA miR-279 leads to the development of CO2-detecting neurons in the MPs, indicating a change in function.
- The resulting hybrid neurons possess characteristics of both CO2 and MP receptor neurons, suggesting an evolutionary link in how species have adapted their responses to CO2.
Article Abstract
Carbon dioxide (CO2) elicits different olfactory behaviors across species. In Drosophila, neurons that detect CO2 are located in the antenna, form connections in a ventral glomerulus in the antennal lobe, and mediate avoidance. By contrast, in the mosquito these neurons are in the maxillary palps (MPs), connect to medial sites, and promote attraction. We found in Drosophila that loss of a microRNA, miR-279, leads to formation of CO2 neurons in the MPs. miR-279 acts through down-regulation of the transcription factor Nerfin-1. The ectopic neurons are hybrid cells. They express CO2 receptors and form connections characteristic of CO2 neurons, while exhibiting wiring and receptor characteristics of MP olfactory receptor neurons (ORNs). We propose that this hybrid ORN reveals a cellular intermediate in the evolution of species-specific behaviors elicited by CO2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714168 | PMC |
| http://dx.doi.org/10.1126/science.1149483 | DOI Listing |
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