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The metabolic effects of intermittent versus continuous feeding in critically ill patients.
Sci Rep
November 2023
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Intermittent (or bolus) feeding regimens in critically ill patients have been of increasing interest to clinicians and scientists. Changes in amino acid, fat and carbohydrate metabolites over time might yet deliver other benefits (e.g.
View Article and Find Full Text PDFRelationship Between Skeletal Muscle Area and Density and Clinical Outcome in Adults Receiving Venovenous Extracorporeal Membrane Oxygenation.
Crit Care Med
April 2021
Department of Critical Care, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Objectives: To investigate the prevalence of low skeletal muscle index (area normalized for height) and density, their trajectory of change, and to determine associations with clinical outcome in adults with severe respiratory failure requiring venovenous extracorporeal membrane oxygenation.
Design: Prospective observational study.
Patients: Adults receiving venovenous extracorporeal membrane oxygenation for a minimum of 72 hours and a maximum of 6 months between September 2010 and June 2017, who had a CT scan which included the third lumbar vertebra.
On baseball and breast cancer.
Am J Surg
March 2018
Department of Surgery, Yale University School of Medicine, United States. Electronic address:
Dedicated to the memory of Dr. William Hunter Harridge and Nonie Lowry, this manuscript discusses the ups and downs associated with novel therapies in breast cancer, and applies the lessons of persistence learned from baseball to our quest for more optimal treatments, particularly in triple negative breast cancer.
View Article and Find Full Text PDFWilliam Hunter Harridge lecture: The changing face of short-gut syndrome management.
Am J Surg
March 2017
University of Chicago, Pritzker School of Medicine, USA. Electronic address:
The evolution of managing short gut syndrome optimizes management and decision making of intestinal failure by way of a multidisciplinary team utilizing the latest advances in therapeutic options. Only the minority of patients referred for small bowel transplantation will actually need a transplant. Many of these patients can be rehabilitated without the need for transplant, by way of early referral, and thus the likelihood of medical therapy increases.
View Article and Find Full Text PDF2015 William Hunter Harridge lecture: how did we go from operating on nearly all injured kidneys to operating on almost none of them?
Am J Surg
March 2016
Department of Urology, Detroit Medical Center, Michigan State College of Medicine, Harper Professional Building, Suite 1017, 4160 John R, Detroit, MI 48201, USA. Electronic address:
The 2015 William H. Harridge lecture of the 2015 Midwest Surgical Association concentrated on the evolution and performance characteristics of nonoperative management of even severe renal injury. One of the first mentions of nonoperative renal trauma occurs after World War II.
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