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Comparative transcriptomic rhythms in the mouse and human prefrontal cortex.
Front Neurosci
January 2025
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Introduction: Alterations in multiple subregions of the human prefrontal cortex (PFC) have been heavily implicated in psychiatric diseases. Moreover, emerging evidence suggests that circadian rhythms in gene expression are present across the brain, including in the PFC, and that these rhythms are altered in disease. However, investigation into the potential circadian mechanisms underlying these diseases in animal models must contend with the fact that the human PFC is highly evolved and specialized relative to that of rodents.
View Article and Find Full Text PDFSignaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review.
Bone Res
January 2025
Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Circadian rhythm is ubiquitous in nature. Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, and regulate a variety of physiological and pathological processes, including bone and cartilage metabolism. Deletion of the core clock gene Bmal1 leads to pathological bone alterations, while the phenotypes are not consistent.
View Article and Find Full Text PDFPrevalence and risks of sleep bruxism in children and adolescents presenting for orthodontic treatment.
Eur J Orthod
December 2024
Department of Orthodontics, School of Dental Medicine, University at Buffalo, 3435 Main Street, Buffalo, NY 14214, United States.
Objectives: This study determined the prevalence and risks of definite sleep bruxism (SB) among children and adolescents presenting for orthodontic treatment.
Methods: This was a cross-sectional study of 7-16-year-old subjects pursuing orthodontic treatment for the first time. The presence or absence of SB was determined using an overnight mandibular movement monitoring inertial measurement sensor, worn by each participant for two consecutive nights.
Human sleep and immunity: The role of circadian patterns.
Handb Clin Neurol
January 2025
Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Faculty of Health Sciences, Universidad Autónoma de Chile, Providencia, Chile. Electronic address:
It is well established that sleep promotes health and welfare. Literature data suggests that sleep is a recurrent resting state that performs multiple biological functions, such as memory consolidation and regulation of glucose, lipid metabolism, energy metabolism, eating behavior, and blood pressure, besides, regulating the immune system. These immunological functions depend on regular sleep and circadian rhythms, as both impact the magnitude of immune responses.
View Article and Find Full Text PDFSleep and circadian rhythms modeling: From hypothalamic regulatory networks to cortical dynamics and behavior.
Handb Clin Neurol
January 2025
School of Physics, Faculty of Science, University of Sydney, Camperdown, NSW, Australia.
Sleep and circadian rhythms are regulated by dynamic physiologic processes that operate across multiple spatial and temporal scales. These include, but are not limited to, genetic oscillators, clearance of waste products from the brain, dynamic interplay among brain regions, and propagation of local dynamics across the cortex. The combination of these processes, modulated by environmental cues, such as light-dark cycles and work schedules, represents a complex multiscale system that regulates sleep-wake cycles and brain dynamics.
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