A novel particulate nanofibrous hydroxyapatite (HA), which mimics the bone matrix, is presented as a surface functional material to modify silicon wafers by the electrospinning method. The HA precursors were treated with viscous polymer solution, and then electrospun under controlled conditions. After successive calcinations, the powder X-ray diffraction patterns of the samples revealed reflection toward the (300) HA plane that is linear with temperature. This prominent reflection suggests the crystallographic purity of the HA. Biocompatibility, cell proliferation, and microstructure were examined using AFM and FE-SEM. Morphology showed cell spreading and penetration instead of cell aggregation. The surface roughness as well as adhesion force was calculated using contact mode AFM. The results show that the composite matrix holds promise for use as a bone implant material.
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http://dx.doi.org/10.1002/jbm.a.31779 | DOI Listing |
Int J Biol Macromol
January 2025
Department of Pharmaceutical Analysis, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, The School of Pharmacy, Fujian Medical University, Fuzhou 350122, China. Electronic address:
Since cartilage injury is often accompanied by subchondral bone damage, conventional single-phase materials cannot accurately simulate the osteochondral structure or repair osteochondral injury. In this work, a gradient gelatin-methacryloyl (GelMA) hydrogel scaffold was constructed by a layer-by-layer stacking method to realize full-thickness regeneration of cartilage, calcified cartilage and subchondral bone. Of note, to surmount the inadequate mechanical property of GelMA hydrogel, nanohydroxyapatite (nHA) was incorporated and further functionalized with hydroxyethyl methacrylate (nHA-hydroxyethyl methacrylate, nHAMA) to enhance the interfacial adhesion with the hydrogel, resulting in better mechanical strength akin to human bone.
View Article and Find Full Text PDFBiomater Sci
January 2025
Department of Chemistry, Amrita Vishwa Vidyapeetham, Amritapuri, Kollam, India.
Hydroxyapatite (HA), the main inorganic bone component, is the most widely researched bioceramic for bone repair. This paper presents a comprehensive review of recent advancements in HA synthesis methods and their integration into additive manufacturing (AM) processes. Synthesis methodologies discussed include wet, dry, and biomimetic routes, emphasizing their impact on tailoring the physicochemical properties of HA for biomedical applications.
View Article and Find Full Text PDFInt Dent J
January 2025
Department of Microbiology, University of Dhaka, Dhaka, Dhaka, Bangladesh.
Hydroxyapatite nanoparticles (HANPs) are becoming increasingly crucial in dental implant applications as they are highly compatible with biological systems, actively support biological processes, and closely resemble bone minerals. This review covers the latest progress in how HANPs are made, studied, and used in dentistry. It looks at critical methods for creating HANPs, such as sol-gel, microwave hydrothermal synthesis, and biomimetic approaches, and how they affect the particles' size, structure, and activity.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Center of Translational Oral Research (TOR), Department of Clinical Dentistry, University of Bergen, 5009 Bergen, Norway.
Bioprinting of nanohydroxyapatite (nHA)-based bioinks has attracted considerable interest in bone tissue engineering. However, the role and relevance of the physicochemical properties of nHA incorporated in a bioink, particularly in terms of its printability and the biological behavior of bioprinted cells, remain largely unexplored. In this study, two bioinspired nHAs with different chemical compositions, crystallinity, and morphologies were synthesized and characterized: a more crystalline, needle-like Mg-doped nHA (N-HA) and a more amorphous, rounded Mg- and CO-doped nHA (R-HA).
View Article and Find Full Text PDFJ Biomater Appl
January 2025
Biomedical Engineering Graduate Program, Toronto Metropolitan University, Toronto, ON, Canada.
This study explores mesoporous bioactive glasses (MBGs) that show promise as advanced therapeutic delivery platforms owing to their tailorable porous properties enabling enhanced drug loading capacity and biomimetic chemistry for localized, sustained release. This work systematically investigates the complex relationship between MBG composition and surfactant templating on structural evolution, bioactive response, resultant drug loading efficiency and release. A total of 12 samples of sol-gel-derived MBG were synthesized using cationic and non-ionic structure-directing agents (cetyltrimethylammonium bromide, Pluronic F127 and P123) while modulating the SiO/CaO content, generating MBG with surface areas of 60-695 m/g.
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