AI Article Synopsis
- Excessive proinflammatory cytokines caused by staphylococcal exotoxins lead to toxic effects, prompting the study of antioxidant treatments.
- N-acetyl-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) significantly reduced T-cell proliferation and cytokine production induced by staphylococcal enterotoxins in human immune cells.
- Both antioxidants were effective due to their ability to inhibit NF-kappaB activation, suggesting a potential therapeutic role in managing superantigen-related pathologies.
Article Abstract
Excessive release of proinflammatory cytokines and chemokines mediates the toxic effects of superantigenic staphylococcal exotoxins (SE). We evaluated the potency of two anti-oxidants, N-acetyl-cysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) in inhibiting the staphylococcal enterotoxin B and staphylococcal toxic shock syndrome-1-induced activation of human peripheral blood mononuclear cells (PBMC). Both NAC and PDTC dose-dependently inhibited SE-stimulated T-cell proliferation (by 98%), production of cytokines and chemokines by PBMC and expression of SE-induced cell surface activation markers. The potency of both NAC and PDTC corresponded to their ability to inhibit NF-kappaB activation. Our results suggest that anti-oxidants might be useful to mitigate the pathogenic effects of SE by blocking transcriptional signaling activated by superantigens.
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| http://dx.doi.org/10.1080/08923970701692577 | DOI Listing |
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