Protease-activated receptor-2 (PAR-2) is known to be involved in epidermal permeability barrier function homeostasis. PAR-2 activation occurs after barrier disruption and further activation of PAR-2 by activating peptide significantly delays barrier recovery rate. Cockroach and house dust mite allergens, both known to be associated with the development of asthma, allergic rhinitis, and atopic dermatitis, have protease activity, which can activate PAR-2. In this study, we investigated the effects of both allergens on the epidermal barrier function as well as on the epidermal calcium gradient. Both allergens, when topically applied on the barrier-disrupted site, increased protease activities in the epidermis and delayed barrier recovery and lamellar body secretion in murine skin. The topical application of PAR-2-specific antagonist or protease inhibitors normalized the barrier recovery. Cockroach allergens induced intracellular calcium oscillations in cultured human keratinocytes through PAR-2-involved pathway, which was confirmed by desensitization protocol. Abnormal calcium ion distribution after barrier disruption was also observed in allergens-applied skin. These results suggest that allergens with protease activity can influence the epidermal permeability barrier homeostasis through PAR-2 activation and consequent modulation of the calcium ions in skin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/jid.2008.13 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Digital health interventions in adult intensive care and recovery after critical illness to promote survivorship care.
J Intensive Care Soc
January 2025
Department of Physiotherapy, Faculty of Medicine, Dentistry and Health Sciences, School of Health Sciences, The University of Melbourne, Melbourne, VIC, Australia.
Digital health refers to the field of using and developing technology to improve health outcomes. Digital health and digital health interventions (DHIs) within the area of intensive care and critical illness survivorship are rapidly evolving. Digital health interventions refer to technologies in clinical interventional format.
View Article and Find Full Text PDFEnhancing Compliance With Preoperative Fasting Guidelines: A Closed-Loop Quality Improvement Initiative to Optimize Patient Safety and Outcomes.
Cureus
December 2024
Cardiothoracic Surgery, Moscow Regional Research and Clinical Institute, Moscow, RUS.
Introduction Preoperative fasting is essential in surgical care to reduce the risk of pulmonary aspiration during anesthesia. International guidelines, such as those from the American Society of Anesthesiologists (ASA) and the European Society of Anaesthesiology (ESA), recommend fasting durations of six hours for solids and two hours for clear liquids. However, adherence to these guidelines often varies in clinical practice, leading to prolonged fasting times that can negatively impact patient outcomes, including dehydration, hypoglycemia, discomfort, and delayed recovery.
View Article and Find Full Text PDF: Recovery management checkups done in primary care settings (RMC-PCs) can be an effective intervention to link individuals with substance use disorders (SUD) to treatment and help them stay engaged with treatment. There is reason to question, however, whether RMC-PCs are as effective for those who have been recently incarcerated or for those holding a minoritized, racial identity. : We examined data from a randomized controlled trial of RMC-PCs compared to a control condition ( = 266).
View Article and Find Full Text PDFSubstance use recovery needs among college students seeking recovery services: a thematic qualitative analysis.
Addict Sci Clin Pract
January 2025
Department of Counseling Psychology and Human Services, University of Oregon, Eugene, OR, USA.
Background: College students who are in recovery from substance use disorders face challenges related to abstaining from substance use, finding supportive social networks, and achieving their academic goals. These students may therefore seek out various recovery supports at their institutions to meet their needs and goals.
Methods: This study analyzed previously collected data to explore themes related to students' experiences of recovery, including their recovery needs and challenges while also attending college.
Intensive Outreach for Mental Health: Young People's Experiences of an Intensive Outreach Model on Recovery and Engagement.
Community Ment Health J
January 2025
School of Psychology and Public Health, La Trobe University, Plenty Road & Kingsbury Drive, Bundoora, VIC, 3086, Australia.
Engagement with traditional mental health services can be particularly challenging for young people experiencing severe and complex mental health problems. Assertive community treatment-based services providing mobile outreach, such as Intensive Mobile Youth Outreach Services (IMYOS), operate across Australia to support these young people's mental health needs in the transition to adulthood. Past research on IMYOS has focused on quantitative outcome measures, and young people's experiences of this type of model are poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!