The synthesis and the structure activity of a new series of pyrrolo[1,2-a]pyrazine is reported. These molecules are potent and selective non-competitive mGluR5 antagonists and may shed new light on the pattern of substitution tolerated by this receptor.
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| http://dx.doi.org/10.1016/j.bmcl.2008.02.024 | DOI Listing |
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