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In vitro antimicrobial susceptibility of Mycobacterium abscessus in Korea. | LitMetric

In vitro antimicrobial susceptibility of Mycobacterium abscessus in Korea.

J Korean Med Sci

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Published: February 2008

AI Article Synopsis

  • - Mycobacterium abscessus is a leading cause of lung disease from nontuberculous mycobacteria in Korea, yet antimicrobial susceptibility tests for it had not been conducted until now.
  • - Researchers tested 74 isolates against eight antibiotics, revealing that amikacin and cefoxitin were highly effective (99% susceptibility), while clarithromycin also showed strong activity (91%).
  • - The study emphasizes that there are significant differences in antibiotic susceptibility among isolates, indicating that each clinically relevant M. abscessus isolate needs to be tested individually for effective treatment.

Article Abstract

Mycobacterium abscessus is the second most common etiology of pulmonary disease caused by nontuberculous mycobacteria in Korea. Although antimicrobial susceptibility tests are important for appropriate patient management in M. abscessus lung disease, the tests have never been investigated in Korea. Seventy-four isolates of M. abscessus recovered from patient respiratory samples were tested against eight antimicrobial agents following the guidelines set forth by the National Committee for Clinical Laboratory Standards. Of the parenteral antibiotics, amikacin (99%, 73/74) and cefoxitin (99%, 73/74) were active against most isolates. Imipenem (55%, 36/66) and tobramycin (36%, 27/74) had activity against moderate number of isolates. Of the oral antibiotics, clarithromycin (91%, 67/74) was active against the majority of isolates. Moxifloxacin (73%, 54/74) and ciprofloxacin (57%, 42/74) had activity against a moderate number of isolates. Doxycycline was the least active, inhibiting only 7% (5/74) of isolates. In conclusion, the variations in susceptibility within M. abscessus isolates to currently available antimicrobials suggest that the antimicrobial susceptibilities of any clinically significant M. abscessus isolate be needed individually.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526484PMC
http://dx.doi.org/10.3346/jkms.2008.23.1.49DOI Listing

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